Maternal/neonatal Vitamin D Deficiency: a Risk Factor for Bronchopulmonary Dysplasia in Preterms?

Overview

Journal J Perinatol

Specialty Gynecology & Obstetrics

Date 2015 Jul 31

PMID 26226242

Citations 27

Authors

M Cetinkaya

F Cekmez

T Erener-Ercan

G Buyukkale

A Demirhan

G Aydemir

F N Aydin

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of bronchopulmonary dysplasia.

Study Design: One hundred and thirty-two preterm infants ⩽32 weeks of gestation who were diagnosed with respiratory distress syndrome were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit.

Result: A total of 100 infants were included and 31 (31%) developed bronchopulmonary dysplasia (BPD). Both maternal and neonatal 25-OHD levels in the BPD group were significantly lower compared with those in the no-BPD group (P=0.0001). A positive correlation was detected between maternal and neonatal 25-OHD levels. All of the infants with BPD had a 25-OHD level <10 ng ml(-1), which represented severe deficiency. Univariate logistic regression analysis revealed that maternal/neonatal vitamin D levels were a significant predictor of BPD (odds ratio (OR): 0.76 and 0.61, respectively, P<0.001).

Conclusion: We demonstrated for the first time that lower maternal and neonatal vitamin 25-OHD levels were associated with BPD development in preterm infants. However, further studies with larger sample sizes are needed to delineate the possible link between vitamin D deficiency and BPD.

Citing Articles

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Shadid I, Brustad N, Lu M, Chawes B, Bisgaard H, Zeiger R Am J Clin Nutr. 2023; 117(6):1342-1352.

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Vitamin d deficiency with high parathyroid hormone levels is related to late onset SEPSIS among preterm infants.

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Barut D, Akisu M, Altun Koroglu O, Terek D, Ergin F, Onay H Pediatr Res. 2023; 94(1):275-279.

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Association of Maternal Hypertensive Disorders During Pregnancy With Severe Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.

Lim G, Kim Y, Chung S, Park Y, Kim K, Park H J Korean Med Sci. 2022; 37(16):e127.

PMID: 35470601 PMC: 9039196. DOI: 10.3346/jkms.2022.37.e127.

References

BOSTROM H, Willetts K, Pekny M, Leveen P, Lindahl P, Hedstrand H . PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell. 1996; 85(6):863-73. DOI: 10.1016/s0092-8674(00)81270-2. View

Marin L, Dufour M, Tordet C, Nguyen M . 1,25(OH)2D3 stimulates phospholipid biosynthesis and surfactant release in fetal rat lung explants. Biol Neonate. 1990; 57(3-4):257-60. DOI: 10.1159/000243200. View

Wagner C, Greer F . Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008; 122(5):1142-52. DOI: 10.1542/peds.2008-1862. View

Van Marter L . Epidemiology of bronchopulmonary dysplasia. Semin Fetal Neonatal Med. 2009; 14(6):358-66. DOI: 10.1016/j.siny.2009.08.007. View

Sakurai R, Shin E, Fonseca S, Sakurai T, Litonjua A, Weiss S . 1alpha,25(OH)2D3 and its 3-epimer promote rat lung alveolar epithelial-mesenchymal interactions and inhibit lipofibroblast apoptosis. Am J Physiol Lung Cell Mol Physiol. 2009; 297(3):L496-505. PMC: 2739775. DOI: 10.1152/ajplung.90539.2008. View

Torday J, Rehan V . A cell-molecular approach predicts vertebrate evolution. Mol Biol Evol. 2011; 28(11):2973-81. PMC: 3199438. DOI: 10.1093/molbev/msr134. View

Camargo Jr C, Rifas-Shiman S, Litonjua A, Rich-Edwards J, Weiss S, Gold D . Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr. 2007; 85(3):788-95. PMC: 4406411. DOI: 10.1093/ajcn/85.3.788. View

Ormerod A, Xing Z, Pedigo N, Mishra A, Kaetzel D . The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. Exp Lung Res. 2008; 34(4):155-82. PMC: 2747600. DOI: 10.1080/01902140801929325. View

Ramirez A, Wongtrakool C, Welch T, Steinmeyer A, Zugel U, Roman J . Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol. 2009; 118(3):142-50. PMC: 2821704. DOI: 10.1016/j.jsbmb.2009.11.004. View

10.

Nguyen M, Guillozo H, Garabedian M, BALSAN S . Lung as a possible additional target organ for vitamin D during fetal life in the rat. Biol Neonate. 1987; 52(4):232-40. DOI: 10.1159/000242714. View

11.

Cetinkaya M, Cekmez F, Buyukkale G, Erener-Ercan T, Demir F, Tunc T . Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants. J Perinatol. 2014; 35(1):39-45. DOI: 10.1038/jp.2014.146. View

12.

Miyake Y, Sasaki S, Tanaka K, Hirota Y . Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur Respir J. 2009; 35(6):1228-34. DOI: 10.1183/09031936.00100609. View

13.

Mathews T, Minino A, Osterman M, Strobino D, Guyer B . Annual summary of vital statistics: 2008. Pediatrics. 2010; 127(1):146-57. DOI: 10.1542/peds.2010-3175. View

14.

Ozkan H, Cetinkaya M, Koksal N . Increased incidence of bronchopulmonary dysplasia in preterm infants exposed to preeclampsia. J Matern Fetal Neonatal Med. 2012; 25(12):2681-5. DOI: 10.3109/14767058.2012.708371. View

15.

Nguyen M, Trubert C, Rizk-Rabin M, Rehan V, BESANCON F, Cayre Y . 1,25-Dihydroxyvitamin D3 and fetal lung maturation: immunogold detection of VDR expression in pneumocytes type II cells and effect on fructose 1,6 bisphosphatase. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):93-7. DOI: 10.1016/j.jsbmb.2004.03.054. View

16.

Kho A, Bhattacharya S, Tantisira K, Carey V, Gaedigk R, Leeder J . Transcriptomic analysis of human lung development. Am J Respir Crit Care Med. 2009; 181(1):54-63. PMC: 2797628. DOI: 10.1164/rccm.200907-1063OC. View

17.

Nguyen T, Guillozo H, Marin L, Tordet C, Koite S, Garabedian M . Evidence for a vitamin D paracrine system regulating maturation of developing rat lung epithelium. Am J Physiol. 1996; 271(3 Pt 1):L392-9. DOI: 10.1152/ajplung.1996.271.3.L392. View

18.

Stoll B, Hansen N, Bell E, Shankaran S, Laptook A, Walsh M . Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010; 126(3):443-56. PMC: 2982806. DOI: 10.1542/peds.2009-2959. View

19.

Coalson J . Pathology of bronchopulmonary dysplasia. Semin Perinatol. 2006; 30(4):179-84. DOI: 10.1053/j.semperi.2006.05.004. View

20.

Erkkola M, Kaila M, Nwaru B, Kronberg-Kippila C, Ahonen S, Nevalainen J . Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin Exp Allergy. 2009; 39(6):875-82. DOI: 10.1111/j.1365-2222.2009.03234.x. View