Cytotoxic and Antibacterial Compounds from the Coral-Derived Fungus Aspergillus Tritici SP2-8-1

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2017 Nov 8

PMID 29112138

Citations 20

Authors

Weiyi Wang

Yanyan Liao

Chao Tang

Xiaomei Huang

Zhuhua Luo

Jianming Chen

Peng Cai

Affiliations

Soon will be listed here.

Abstract

Three novel compounds, 4-methyl-candidusin A (), aspetritone A () and aspetritone B (), were obtained from the culture of a coral-derived fungus SP2-8-1, together with fifteen known compounds (-). Their structures, including absolute configurations, were assigned based on NMR, MS, and time-dependent density functional theory (TD-DFT) ECD calculations. Compounds and exhibited better activities against methicillin-resistant strains of (MRSA) ATCC 43300 and MRSA CGMCC 1.12409 than the positive control chloramphenicol. Compound displayed stronger anti-MRSA and lower cytotoxic activities than , and showed stronger antibacterial activities against strains of , , and than the other compounds. Compounds and exhibited significantly stronger cytotoxic activities against human cancer cell lines HeLa, A549, and Hep G2 than the other compounds. Preliminary structure-activity relationship studies indicated that prenylation of terphenyllin or candidusin and the tetrahydrobenzene moiety in anthraquinone derivatives may influence their bioactivity.

Citing Articles

Marine Fungi: A Prosperous Source of Novel Bioactive Natural Products.

Ji R, Zha X, Zhou S Curr Med Chem. 2023; 32(5):992-1006.

PMID: 37885109 DOI: 10.2174/0109298673266304231015070956.

Insights into metabolic and pharmacological profiling of Aspergillus ficuum through bioinformatics and experimental techniques.

Shah Z, Khan K, Rashid H, Shah T, Jaremko M, Iqbal Z BMC Microbiol. 2022; 22(1):295.

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Anthraquinones and Their Analogues from Marine-Derived Fungi: Chemistry and Biological Activities.

Hafez Ghoran S, Taktaz F, Ayatollahi S, Kijjoa A Mar Drugs. 2022; 20(8).

PMID: 35892942 PMC: 9394430. DOI: 10.3390/md20080474.

Antibacterial Molecules from Marine Microorganisms against Aquatic Pathogens: A Concise Review.

Guo S, Zhang Z, Guo L Mar Drugs. 2022; 20(4).

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Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer.

Yu D, Qi S, Guan X, Yu W, Yu X, Cai M Front Pharmacol. 2022; 13:870367.

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