Effect of Mycelia Extract on Exercise Performance and Physical Fatigue in Mice

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2017 Nov 7

PMID 29104465

Citations 5

Authors

Chun-Sheng Ho

Yu-Tang Tung

Woon-Man Kung

Wen-Ching Huang

Wing-Ki Leung

Chi-Chang Huang

Jyh-Horng Wu

Affiliations

Soon will be listed here.

Abstract

In this study, mycelia (CVM) was evaluated the ergogenic and anti-fatigue activities. Male ICR mice were divided into four groups ( = 8/group) to receive vehicle or CVM by oral gavage for 4 weeks at 0, 615, 1230 or 3075 mg/kg/day, which were respectively designated the vehicle, CVM-1X, CVM-2X and CVM-5X groups. Forelimb grip strength, endurance swimming time, and levels of physical fatigue-associated parameters serum lactate, ammonia, glucose and creatine kinase (CK) after physical challenge were performed to evaluate exercise performance and anti-fatigue activity. Results revealed that the forelimb grip strength of mice in group CVM-1X, CVM-2X and CVM-5X were significantly increased by 1.20-, 1.18- and 1.23-fold, respectively, compared to the vehicle group. After the 15 minute swimming exercise, the levels of serum lactate of CVM-1X, CVM-2X and CVM-5X groups were significantly lower than the vehicle control group by 29%, 23% and 31%, respectively. The levels of ammonia in CVM-1X, CVM-2X and CVM-5X groups were significantly lowered by 22%, 25% and 41%, respectively, compared to the vehicle control group. In addition, the levels of serum CK in CVM-2X and CVM-5X groups were significantly lowered by 13% and 11%, respectively, compared to the vehicle control group. Accordingly, the supplementation with CVM has beneficial effects on performance improvement and anti-fatigue activity, and thus has great potential as a source for natural health products.

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References

Kim K, Yu K, Kang D, Suh H . Anti-stress and anti-fatigue effect of fermented rice bran. Phytother Res. 2002; 16(7):700-2. DOI: 10.1002/ptr.1019. View

Wang S, Huang W, Liu C, Wang M, Ho C, Huang W . Pumpkin (Cucurbita moschata) fruit extract improves physical fatigue and exercise performance in mice. Molecules. 2012; 17(10):11864-76. PMC: 6268989. DOI: 10.3390/molecules171011864. View

Cui J, Chisti Y . Polysaccharopeptides of Coriolus versicolor: physiological activity, uses, and production. Biotechnol Adv. 2003; 21(2):109-22. DOI: 10.1016/s0734-9750(03)00002-8. View

Chen W, Huang W, Chiu C, Chang Y, Huang C . Whey protein improves exercise performance and biochemical profiles in trained mice. Med Sci Sports Exerc. 2014; 46(8):1517-24. PMC: 4186725. DOI: 10.1249/MSS.0000000000000272. View

Jin H, Wei P . Anti-fatigue properties of tartary buckwheat extracts in mice. Int J Mol Sci. 2011; 12(8):4770-80. PMC: 3179131. DOI: 10.3390/ijms12084770. View

Tan W, Yu K, Liu Y, Ouyang M, Yan M, Luo R . Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae Preparata. Int J Biol Macromol. 2011; 50(1):59-62. DOI: 10.1016/j.ijbiomac.2011.09.019. View

Koo H, Lee J, Hong S, Kim H . Herbkines increases physical stamina in mice. Biol Pharm Bull. 2004; 27(1):117-9. DOI: 10.1248/bpb.27.117. View

Wang J, Li S, Fan Y, Chen Y, Liu D, Cheng H . Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer. J Ethnopharmacol. 2010; 130(2):421-3. DOI: 10.1016/j.jep.2010.05.027. View

Huang C, Hsu M, Huang W, Yang H, Hou C . Triterpenoid-Rich Extract from Antrodia camphorata Improves Physical Fatigue and Exercise Performance in Mice. Evid Based Complement Alternat Med. 2012; 2012:364741. PMC: 3398672. DOI: 10.1155/2012/364741. View

10.

Zhang Y, Yao X, Bao B, Zhang Y . Anti-fatigue activity of a triterpenoid-rich extract from Chinese bamboo shavings (Caulis bamfusae in taeniam). Phytother Res. 2006; 20(10):872-6. DOI: 10.1002/ptr.1965. View

11.

Tanaka M, Nakamura F, Mizokawa S, Matsumura A, Nozaki S, Watanabe Y . Establishment and assessment of a rat model of fatigue. Neurosci Lett. 2003; 352(3):159-62. DOI: 10.1016/j.neulet.2003.08.051. View

12.

Belluardo N, Westerblad H, Mudo G, Casabona A, Bruton J, Caniglia G . Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4. Mol Cell Neurosci. 2001; 18(1):56-67. DOI: 10.1006/mcne.2001.1001. View

13.

Uthayathas S, Karuppagounder S, Ilbasmis Tamer S, Parameshwaran K, Degim T, Suppiramaniam V . Evaluation of neuroprotective and anti-fatigue effects of sildenafil. Life Sci. 2007; 81(12):988-92. DOI: 10.1016/j.lfs.2007.07.018. View

14.

Prado E, de Rezende Neto J, de Almeida R, de Melo M, Cameron L . Keto analogue and amino acid supplementation affects the ammonaemia response during exercise under ketogenic conditions. Br J Nutr. 2011; 105(12):1729-33. DOI: 10.1017/S000711451000557X. View

15.

Wu R, Huang W, Liao C, Chang Y, Kan N, Huang C . Resveratrol protects against physical fatigue and improves exercise performance in mice. Molecules. 2013; 18(4):4689-702. PMC: 6270062. DOI: 10.3390/molecules18044689. View

16.

Zheng S, Jiang F, Gao H, Zheng J . Preliminary observations on the antifatigue effects of longan (Dimocarpus longan Lour.) seed polysaccharides. Phytother Res. 2010; 24(4):622-4. DOI: 10.1002/ptr.2963. View

17.

Li X, Zhang H, Xu H . Analysis of chemical components of shiitake polysaccharides and its anti-fatigue effect under vibration. Int J Biol Macromol. 2009; 45(4):377-80. DOI: 10.1016/j.ijbiomac.2009.07.005. View

18.

Tharakan B, Dhanasekaran M, Brown-Borg H, Manyam B . Trichopus zeylanicus combats fatigue without amphetamine-mimetic activity. Phytother Res. 2006; 20(3):165-8. DOI: 10.1002/ptr.1773. View

19.

Zhang H, Li J, Li G, Wang D, Zhu L, Yang D . Structural characterization and anti-fatigue activity of polysaccharides from the roots of Morinda officinalis. Int J Biol Macromol. 2009; 44(3):257-61. DOI: 10.1016/j.ijbiomac.2008.12.010. View

20.

Warren G, Ingalls C, Lowe D, Armstrong R . Excitation-contraction uncoupling: major role in contraction-induced muscle injury. Exerc Sport Sci Rev. 2001; 29(2):82-7. DOI: 10.1097/00003677-200104000-00008. View