Clinical Significance of Tensin 4 Gene Expression in Patients with Gastric Cancer

Overview

Journal In Vivo

Specialty Oncology

Date 2017 Nov 6

PMID 29102927

Citations 12

Authors

Sho Sawazaki

Takashi Oshima

Kentaro Sakamaki

Toru Aoyama

Tsutomu Sato

Manabu Shiozawa

Takaki Yoshikawa

Yasushi Rino

Toshio Imada

Munetaka Masuda

Affiliations

Soon will be listed here.

Abstract

Background: Overall survival remains unsatisfactory in stage II/III gastric cancer, even after curative resection and adjuvant chemotherapy. Tensin 4 (TNS4), a cell adhesion factor, is associated with cancer-cell motility and migration.

Patients And Methods: We examined the clinical significance of TNS4 gene expression in 134 patients with stage II/III gastric cancer who underwent adjuvant chemotherapy with S-1. TNS4 gene expression in surgical specimens was measured by quantitative reverse-transcription polymerase chain reaction (RT-PCR).

Results: TNS4 gene expression levels were significantly higher in cancer tissue than in adjacent normal mucosa. High TNS4 gene expression was associated with significantly poorer 5-year overall survival than was low expression. On multivariate analysis, TNS4 gene expression was an independent prognostic factor.

Conclusion: Overexpression of the TNS4 gene is a useful independent predictor of outcomes in patients with stage II/III gastric cancer who undergo surgery and receive adjuvant chemotherapy with S-1.

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