Tensins - Emerging Insights into Their Domain Functions, Biological Roles and Disease Relevance

Overview

Journal J Cell Sci

Specialty Cell Biology

Date 2021 Feb 18

PMID 33597154

Citations 19

Authors

Yi-Chun Liao

Su Hao Lo

Affiliations

Soon will be listed here.

Abstract

Tensins are a family of focal adhesion proteins consisting of four members in mammals (TNS1, TNS2, TNS3 and TNS4). Their multiple domains and activities contribute to the molecular linkage between the extracellular matrix and cytoskeletal networks, as well as mediating signal transduction pathways, leading to a variety of physiological processes, including cell proliferation, attachment, migration and mechanical sensing in a cell. Tensins are required for maintaining normal tissue structures and functions, especially in the kidney and heart, as well as in muscle regeneration, in animals. This Review discusses our current understanding of the domain functions and biological roles of tensins in cells and mice, as well as highlighting their relevance to human diseases.

Citing Articles

A novel isoform of Tensin1 promotes actin filament assembly for efficient erythroblast enucleation.

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Integrative Genomic and Transcriptomic Analysis in Acute Interstitial Pneumonia.

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Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis.

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