The Relationship Between Systemic Iron Homeostasis and Erythropoiesis

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2017 Nov 4

PMID 29097483

Citations 13

Authors

Gautam Rishi

V Nathan Subramaniam

Affiliations

Soon will be listed here.

Abstract

Red blood cell production (erythropoiesis) is the single largest consumer of iron in the body; this need is satisfied by maintaining a sensitive regulation of iron levels. The level of erythropoietic demand regulates the expression of the iron hormone hepcidin and thus iron absorption. Erythropoiesis-mediated regulation of hepcidin is an area of increasing importance and recent studies have identified a number of potential regulatory proteins. This review summarizes our current knowledge about these candidate erythroid regulators of hepcidin and the relation between transferrin receptors and erythropoiesis.

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