Genetics of Type 1 Diabetes

Overview

Journal Pediatr Diabetes

Publisher Wiley

Specialties Endocrinology
Pediatrics

Date 2017 Nov 3

PMID 29094512

Citations 94

Authors

Maria J Redondo

Andrea K Steck

Alberto Pugliese

Affiliations

Soon will be listed here.

Abstract

Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.

Citing Articles

Emerging Immunotherapies for Disease Modification of Type 1 Diabetes.

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PMID: 39873914 DOI: 10.1007/s40265-025-02150-8.

Autoimmune Type 1 Diabetes: An Early Approach Appraisal for Spain by the AGORA Diabetes Collaborative Group.

Gomez-Peralta F, Pines-Corrales P, Santos E, Cuesta M, Gonzalez-Albarran O, Azriel S J Clin Med. 2025; 14(2).

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Pre-Type 1 Diabetes in Adolescents and Teens: Screening, Nutritional Interventions, Beta-Cell Preservation, and Psychosocial Impacts.

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Health and Racial Disparities in Diabetes Mellitus Prevalence, Management, Policies, and Outcomes in the United States.

Yedjou C, Sims J, Njiki S, Chitoh A, Joseph M, Cherkos A J Community Med Public Health. 2024; 8(3).

PMID: 39697180 PMC: 11654833. DOI: 10.29011/2577-2228.100460.

Genetic Discovery and Risk Prediction for Type 1 Diabetes in Individuals Without High-Risk HLA-DR3/DR4 Haplotypes.

McGrail C, Chiou J, Egamal R, Elgamal R, Luckett A, Oram R Diabetes Care. 2024; 48(2):202-211.

PMID: 39626097 PMC: 11770152. DOI: 10.2337/dc24-1251.

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