Impaired Hemorheology in Exacerbations of COPD

Overview

Journal Can Respir J

Publisher Wiley

Specialty Pulmonary Medicine

Date 2017 Nov 2

PMID 29089816

Citations 4

Authors

Erhan Ugurlu

Emine Kilic-Toprak

Ilknur Can

Ozgen Kilic-Erkek

Goksel Altinisik

Melek Bor-Kucukatay

Affiliations

Soon will be listed here.

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations.

Materials And Methods: The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations. The severity of COPD was determined according to guidelines. Red blood cell (RBC) deformability and aggregation were measured by an ektacytometer.

Results: RBC deformability of COPD patients with exacerbations was decreased compared to the other groups. Erythrocyte aggregation and plasma fibrinogen of COPD patients determined during exacerbations were higher than control.

Conclusion: Decreased RBC deformability and increased aggregation associated with exacerbations of COPD may serve as unfavorable mechanisms to worsen oxygenation and thus clinical symptoms of the patient. Treatment modalities that modify rheological parameters might be beneficial.

Citing Articles

Chronic Obstructive Pulmonary Disease and Its Effect on Red Blood Cell Indices.

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Erythrocyte Deformability and Na,K-ATPase Activity in Various Pathophysiological Situations and Their Protection by Selected Nutritional Antioxidants in Humans.

Radosinska J, Vrbjar N Int J Mol Sci. 2021; 22(21).

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Impacts of Mycoplasma loads and lung lesions on immune and hematological statuses of pigs in an eight-breed cross heterogeneous population.

Zhang Q, Li J, Huang T, Zhang Y, Xu W, Huang L J Anim Sci. 2020; 98(8).

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Fibrinogen is a promising biomarker for chronic obstructive pulmonary disease: evidence from a meta-analysis.

Zhou B, Liu S, He D, Wang K, Wang Y, Yang T Biosci Rep. 2020; 40(7).

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References

Yang L, Andrews D, Low P . Lysophosphatidic acid opens a Ca(++) channel in human erythrocytes. Blood. 2000; 95(7):2420-5. View

Baskurt O, Boynard M, Cokelet G, Connes P, Cooke B, Forconi S . New guidelines for hemorheological laboratory techniques. Clin Hemorheol Microcirc. 2009; 42(2):75-97. DOI: 10.3233/CH-2009-1202. View

Muravyov A, Draygin S, Eremin N, Muravyov A . The microrheological behavior of young and old red blood cells in athletes. Clin Hemorheol Microcirc. 2002; 26(3):183-8. View

Vestbo J, Hurd S, Agusti A, Jones P, Vogelmeier C, Anzueto A . Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2012; 187(4):347-65. DOI: 10.1164/rccm.201204-0596PP. View

Kirkham P, Barnes P . Oxidative stress in COPD. Chest. 2013; 144(1):266-273. DOI: 10.1378/chest.12-2664. View

Baskurt O, Meiselman H . Analyzing shear stress-elongation index curves: comparison of two approaches to simplify data presentation. Clin Hemorheol Microcirc. 2004; 31(1):23-30. View

Decramer M, Janssens W, Miravitlles M . Chronic obstructive pulmonary disease. Lancet. 2012; 379(9823):1341-51. PMC: 7172377. DOI: 10.1016/S0140-6736(11)60968-9. View

Cicco G, PIRRELLI A . Red blood cell (RBC) deformability, RBC aggregability and tissue oxygenation in hypertension. Clin Hemorheol Microcirc. 2000; 21(3-4):169-77. View

Merinopoulou E, Raluy-Callado M, Ramagopalan S, MacLachlan S, Khalid J . COPD exacerbations by disease severity in England. Int J Chron Obstruct Pulmon Dis. 2016; 11:697-709. PMC: 4824283. DOI: 10.2147/COPD.S100250. View

10.

Langen R, Korn S, Wouters E . ROS in the local and systemic pathogenesis of COPD. Free Radic Biol Med. 2003; 35(3):226-35. DOI: 10.1016/s0891-5849(03)00316-2. View

11.

MacNee W . Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005; 2(1):50-60. DOI: 10.1513/pats.200411-056SF. View

12.

Baskurt O, Meiselman H . Blood rheology and hemodynamics. Semin Thromb Hemost. 2003; 29(5):435-50. DOI: 10.1055/s-2003-44551. View

13.

Straface E, Matarrese P, Gambardella L, Forte S, Carlone S, Libianchi E . N-Acetylcysteine counteracts erythrocyte alterations occurring in chronic obstructive pulmonary disease. Biochem Biophys Res Commun. 2000; 279(2):552-6. DOI: 10.1006/bbrc.2000.3981. View

14.

Pawloski J, Hess D, Stamler J . Export by red blood cells of nitric oxide bioactivity. Nature. 2001; 409(6820):622-6. DOI: 10.1038/35054560. View

15.

Karul A, Karadag F, Kozaci D, Altun C . Erythrocyte fragility is not altered in stable chronic obstructive pulmonary disease with normal arterial pH. Clin Hemorheol Microcirc. 2003; 28(2):107-12. View

16.

Can U, Yerlikaya F, Yosunkaya S . Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease. J Chin Med Assoc. 2015; 78(12):702-8. DOI: 10.1016/j.jcma.2015.08.004. View

17.

Gunay E, Sarinc Ulasli S, Akar O, Ahsen A, Gunay S, Koyuncu T . Neutrophil-to-lymphocyte ratio in chronic obstructive pulmonary disease: a retrospective study. Inflammation. 2013; 37(2):374-80. DOI: 10.1007/s10753-013-9749-1. View

18.

Ugurlu E, Kilic-Toprak E, Altinisik G, Kilic-Erkek O, Cengiz B, Kucukatay V . Increased erythrocyte aggregation and oxidative stress in patients with idiopathic interstitial pneumonia. Sarcoidosis Vasc Diffuse Lung Dis. 2017; 33(4):308-316. View

19.

Baskurt O, Meiselman H . Activated polymorphonuclear leukocytes affect red blood cell aggregability. J Leukoc Biol. 1998; 63(1):89-93. DOI: 10.1002/jlb.63.1.89. View

20.

Duan Y, Zhou M, Xiao J, Wu C, Zhou L, Zhou F . Prediction of key genes and miRNAs responsible for loss of muscle force in patients during an acute exacerbation of chronic obstructive pulmonary disease. Int J Mol Med. 2016; 38(5):1450-1462. PMC: 5065306. DOI: 10.3892/ijmm.2016.2761. View