Perturbed Wnt Signaling Leads to Neuronal Migration Delay, Altered Interhemispheric Connections and Impaired Social Behavior

Overview

Journal Nat Commun

Specialty Biology

Date 2017 Oct 29

PMID 29079819

Citations 36

Authors

Riccardo Bocchi

Kristof Egervari

Laura Carol-Perdiguer

Beatrice Viale

Charles Quairiaux

Mathias De Roo

Michael Boitard

Suzanne Oskouie

Patrick Salmon

Jozsef Z Kiss

Affiliations

Soon will be listed here.

Abstract

Perturbed neuronal migration and circuit development have been implicated in the pathogenesis of neurodevelopmental diseases; however, the direct steps linking these developmental errors to behavior alterations remain unknown. Here we demonstrate that Wnt/C-Kit signaling is a key regulator of glia-guided radial migration in rat somatosensory cortex. Transient downregulation of Wnt signaling in migrating, callosal projection neurons results in delayed positioning in layer 2/3. Delayed neurons display reduced neuronal activity with impaired afferent connectivity causing permanent deficit in callosal projections. Animals with these defects exhibit altered somatosensory function with reduced social interactions and repetitive movements. Restoring normal migration by overexpressing the Wnt-downstream effector C-Kit or selective chemogenetic activation of callosal projection neurons during a critical postnatal period prevents abnormal interhemispheric connections as well as behavioral alterations. Our findings identify a link between defective canonical Wnt signaling, delayed neuronal migration, deficient interhemispheric connectivity and abnormal social behavior analogous to autistic characteristics in humans.

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