Associations Between Emphysema-like Lung on CT and Incident Airflow Limitation: a General Population-based Cohort Study

Overview

Journal Thorax

Date 2017 Oct 28

PMID 29074811

Citations 18

Authors

Elizabeth C Oelsner

Benjamin M Smith

Eric A Hoffman

Aaron R Folsom

Steven M Kawut

Joel D Kaufman

Ani Manichaikul

David J Lederer

Joseph E Schwartz

Karol E Watson

Paul L Enright

John H M Austin

Joao A C Lima

Steven J Shea

Robert G Barr

Affiliations

Soon will be listed here.

Abstract

Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. We used data from 2045 adult participants without initial prebronchodilator airflow limitation, classified by FEV/FVC<0.70, in the Multi-Ethnic Study of Atherosclerosis. Emphysema-like lung on baseline cardiac CT, defined as per cent low attenuation areas>upper limit of normal, was associated with increased odds of incident airflow limitation at 5-year follow-up on both prebronchodilator (adjusted OR 2.62, 95% CI 1.47 to 4.67) and postbronchodilator (adjusted OR 4.38, 95% CI 1.63 to 11.74) spirometry, independent of smoking history. These results support investigation into whether emphysema-like lung could be informative for COPD risk stratification.

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