Possible Mechanism of Acetaldehyde-induced Noradrenaline Release from Sympathetic Nerve Terminals in Isolated Blood Vessels

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1988 Sep 1

PMID 2905902

Citations 2

Authors

S Chiba

M Tsukada

Affiliations

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Abstract

1. Vasoconstrictor responses to acetaldehyde were investigated in isolated and perfused canine intermediate auricular (ear) arteries. 2. Single injections of small doses of acetaldehyde (1-3 mumol) induced vasoconstriction in a dose-related manner and showed no tachyphylaxis. On the other hand, large doses of acetaldehyde (10-30 mumol) frequently caused tachyphylaxis when injected at 10 min intervals. 3. After tyramine treatment, constrictions induced by a large dose of acetaldehyde were consistently restored temporarily. 4. The acetaldehyde-induced vasoconstriction was inhibited by bunazosin, a potent alpha 1-adrenoceptor antagonist. 5. A small dose of imipramine blocked tyramine-induced vasoconstriction, but had no significant influence on noradrenaline (NA)-induced constrictions, and caused slight potentiation of acetaldehyde-induced constrictions. 6. Hydrocortisone treatment did not modify tyramine-induced vasoconstrictions and slightly suppressed NA- and acetaldehyde-induced constrictions but not significantly. 7. It is suggested that acetaldehyde causes a release of NA from a NA store of the sympathetic nerve terminals which is different from the tyramine-sensitive NA store, and that the acetaldehyde-sensitive NA store may be readily filled up with NA from the tyramine-sensitive store.

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References

Bell C . Differential effects of tetrodotoxin on sympathomimetic actions of nicotine and tyramine. Br J Pharmacol Chemother. 1968; 32(1):96-103. PMC: 1570294. DOI: 10.1111/j.1476-5381.1968.tb00433.x. View

Lai F, Hudgins P . A comparison of the indirect sympathomimetic actions of tyramine and acetaldehyde in isolated smooth muscle preparations. Toxicol Appl Pharmacol. 1975; 32(2):368-76. DOI: 10.1016/0041-008x(75)90227-6. View

Kobayashi M, Furukawa Y, Chiba S . Effects of ethanol and acetaldehyde on the isolated, blood-perfused canine atrium. Arch Int Pharmacodyn Ther. 1979; 239(1):109-20. View

Vanhoutte P, Verbeuren T, Webb R . Local modulation of adrenergic neuroeffector interaction in the blood vessel well. Physiol Rev. 1981; 61(1):151-247. DOI: 10.1152/physrev.1981.61.1.151. View

Shoji T . Comparison of pre- and postsynaptic alpha-adrenoceptor blocking effects of E-643 in the isolated vas deferens of the rat. Jpn J Pharmacol. 1981; 31(3):361-8. DOI: 10.1254/jjp.31.361. View

Hongo K, Chiba S . A new method for measuring vascular responsiveness of relatively larger arteries of dogs. J Pharmacol Methods. 1983; 9(1):83-90. DOI: 10.1016/0160-5402(83)90054-2. View

Carlsson A, WALDECK B . MECHANISM OF AMINE TRANSPORT IN THE CELL MEMBRANES OF THE ADRENERGIC NERVES. Acta Pharmacol Toxicol (Copenh). 1965; 22:293-300. DOI: 10.1111/j.1600-0773.1965.tb01824.x. View

Ito T, Chiba S . Vascular responses of isolated canine intermediate auricular artery to vasoactive substances. Arch Int Pharmacodyn Ther. 1984; 268(2):225-31. View

Chiba S, Ito T . Predominant sensitivity to tyramine in the isolated intermediate auricular artery of the dog. J Auton Pharmacol. 1985; 5(2):109-14. DOI: 10.1111/j.1474-8673.1985.tb00111.x. View

10.

Ito T, Chiba S . Existence of two types of postjunctional alpha adrenoceptors in the isolated canine intermediate auricular artery. J Pharmacol Exp Ther. 1985; 234(3):698-702. View

11.

Chiba S, Tsukada M . Potentiating effect of tyramine on acetaldehyde-induced vasoconstriction in isolated dog mesenteric arteries. Jpn J Pharmacol. 1987; 44(3):365-8. DOI: 10.1254/jjp.44.365. View

12.

FURCHGOTT R, KIRPEKAR S, Rieker M, Schwab A . ACTIONS AND INTERACTIONS OF NOREPINEPHRINE, TYRAMINE AND COCAINE ON AORTIC STRIPS OF RABBIT AND LEFT ATRIA OF GUINEA PIG AND CAT. J Pharmacol Exp Ther. 1963; 142:39-58. View

13.

AKABANE J, Nakanishi S, KOHEI H, Matsumura R, Ogata H . STUDIES ON SYMPATHOMIMETIC ACTION OF ACETALDEHYDE. I. EXPERIMENTS WITH BLOOD PRESSURE AND NICTITATING MEMBRANE RESPONSES. Jpn J Pharmacol. 1964; 14:295-307. DOI: 10.1254/jjp.14.295. View

14.

Tsuji T, Chiba S . Potentiating effect of methysergide on norepinephrine-induced constriction of the isolated internal carotid artery of the dog. Jpn J Pharmacol. 1984; 34(1):95-101. DOI: 10.1254/jjp.34.95. View