A Human Lymphoid-specific Transcription Factor That Activates Immunoglobulin Genes is a Homoeobox Protein

Overview

Journal Nature

Specialty Science

Date 1988 Dec 8

PMID 2904654

Citations 140

Authors

C Scheidereit

J A Cromlish

T Gerster

K Kawakami

C G Balmaceda

R A Currie

R G Roeder

Affiliations

Soon will be listed here.

Abstract

The human lymphoid-specific transcription factor OTF-2 contains a homoeodomain that is required for DNA binding and binds specifically to DNA elements that are recognized by Drosophila homoeodomain proteins, suggesting coevolutionary relationships between mammalian and invertebrate homoeodomain proteins and their DNA recognition elements.

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