Recent Advances in Understanding Autoimmune Thyroid Disease: the Tallest Tree in the Forest of Polyautoimmunity

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2017 Oct 19

PMID 29043075

Citations 44

Authors

Sofie Bliddal

Claus Henrik Nielsen

Ulla Feldt-Rasmussen

Affiliations

Soon will be listed here.

Abstract

Autoimmune thyroid disease (AITD) is often observed together with other autoimmune diseases. The coexistence of two or more autoimmune diseases in the same patient is referred to as polyautoimmunity, and AITD is the autoimmune disease most frequently involved. The occurrence of polyautoimmunity has led to the hypothesis that the affected patients suffer from a generalized dysregulation of their immune system. The present review summarizes recent discoveries unravelling the immunological mechanisms involved in autoimmunity, ranging from natural autoimmunity to disease-specific autoimmunity. Furthermore, the clinical grounds for considering AITD in a setting of polyautoimmunity are explored. A better understanding of these may pave the way for designing new treatment modalities targeting the underlying immune dysregulation when AITD appears in the context of polyautoimmunity.

Citing Articles

Allergen Immunotherapy in Autoimmune Terrain: A Case Study.

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The lymphocyte levels of Hashimoto thyroiditis patients were significantly lower than that of healthy population.

Xue H, Xu R Front Endocrinol (Lausanne). 2025; 16:1472856.

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Evaluating the Role of CBC-Derived Indices in Children with Hashimoto's Thyroiditis.

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Beyond the Thyroid: A Narrative Review of Extra-thyroidal Manifestations in Hashimoto's Disease.

Kotak P, Kadam A, Acharya S, Kumar S, Varma A Cureus. 2024; 16(10):e71126.

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Circulating Autoantibodies in Adults with Hashimoto's Thyroiditis: New Insights from a Single-Center, Cross-Sectional Study.

Tripolino O, Mirabelli M, Misiti R, Torchia A, Casella D, Dragone F Diagnostics (Basel). 2024; 14(21).

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