A Genome-wide Association Study Identifies Two New Risk Loci for Graves' Disease

Overview

Journal Nat Genet

Specialty Genetics

Date 2011 Aug 16

PMID 21841780

Citations 134

Authors

Xun Chu

Chun-Ming Pan

Shuang-Xia Zhao

Jun Liang

Guan-Qi Gao

Xiao-Mei Zhang

Guo-Yue Yuan

Chang-Gui Li

Li-Qiong Xue

Min Shen

Wei Liu

Fang Xie

Shao-Ying Yang

Hai-Feng Wang

Jing-Yi Shi

Wei-Wei Sun

Wen-Hua Du

Chun-Lin Zuo

Jin-Xiu Shi

Bing-Li Liu

Cui-Cui Guo

Ming Zhan

Zhao-Hui Gu

Xiao-Na Zhang

Fei Sun

Zhi-Quan Wang

Zhi-Yi Song

Cai-Yan Zou

Wei-Hua Sun

Ting Guo

Huang-Ming Cao

Jun-Hua Ma

Bing Han

Ping Li

He Jiang

Qiu-Hua Huang

Liming Liang

Li-Bin Liu

Gang Chen

Qing Su

Yong-De Peng

Jia-Jun Zhao

Guang Ning

Zhu Chen

Jia-Lun Chen

Sai-Juan Chen

Wei Huang

Huai-Dong Song

Affiliations

Soon will be listed here.

Abstract

Graves' disease is a common autoimmune disorder characterized by thyroid stimulating hormone receptor autoantibodies (TRAb) and hyperthyroidism. To investigate the genetic architecture of Graves' disease, we conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls. We further evaluated a group of associated SNPs in a second set of 3,994 cases and 3,510 controls. We confirmed four previously reported loci (in the major histocompatibility complex, TSHR, CTLA4 and FCRL3) and identified two new susceptibility loci (the RNASET2-FGFR1OP-CCR6 region at 6q27 (P(combined) = 6.85 × 10(-10) for rs9355610) and an intergenic region at 4p14 (P(combined) = 1.08 × 10(-13) for rs6832151)). These newly associated SNPs were correlated with the expression levels of RNASET2 at 6q27, of CHRNA9 and of a previously uncharacterized gene at 4p14, respectively. Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease.

Citing Articles

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Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies.

Wei Y, Zhen J, Hu L, Gu Y, Liu Y, Guo X Nat Commun. 2024; 15(1):8004.

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Smith C, Strausz S, Spence J, Ollila H, Pritchard J medRxiv. 2024; .

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TSHR Gene (rs179247) Polymorphism and Susceptibility to Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis.

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