Aurora Kinase B, a Novel Regulator of TERF1 Binding and Telomeric Integrity

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2017 Oct 18

PMID 29040668

Citations 9

Authors

Foong Lyn Chan

Benjamin Vinod

Karel Novy

Ralf B Schittenhelm

Cheng Huang

Maheshi Udugama

Juan Nunez-Iglesias

Jane I Lin

Linda Hii

Julie Chan

Hilda A Pickett

Roger J Daly

Lee H Wong

Affiliations

Soon will be listed here.

Abstract

AURKB (Aurora Kinase B) is a serine/threonine kinase better known for its role at the mitotic kinetochore during chromosome segregation. Here, we demonstrate that AURKB localizes to the telomeres in mouse embryonic stem cells, where it interacts with the essential telomere protein TERF1. Loss of AURKB function affects TERF1 telomere binding and results in aberrant telomere structure. In vitro kinase experiments successfully identified Serine 404 on TERF1 as a putative AURKB target site. Importantly, in vivo overexpression of S404-TERF1 mutants results in fragile telomere formation. These findings demonstrate that AURKB is an important regulator of telomere structural integrity.

Citing Articles

Aurora B Inhibitors as Cancer Therapeutics.

Kovacs A, Zhao D, Hou J Molecules. 2023; 28(8).

PMID: 37110619 PMC: 10144992. DOI: 10.3390/molecules28083385.

AURKB Enhances Chromosomal Remodeling of Telomeric Genes and Accelerates Tumorigenesis of Uveal Melanoma.

Wang H, Pan H, Huang X Invest Ophthalmol Vis Sci. 2023; 64(4):23.

PMID: 37079315 PMC: 10132317. DOI: 10.1167/iovs.64.4.23.

Telomere Fragility and MiDAS: Managing the Gaps at the End of the Road.

Barnes R, Thosar S, Opresko P Genes (Basel). 2023; 14(2).

PMID: 36833275 PMC: 9956152. DOI: 10.3390/genes14020348.

Aurora B kinase: a potential drug target for cancer therapy.

Ahmed A, Shamsi A, Mohammad T, Hasan G, Islam A, Hassan M J Cancer Res Clin Oncol. 2021; 147(8):2187-2198.

PMID: 34047821 DOI: 10.1007/s00432-021-03669-5.

TERF1 downregulation promotes the migration and invasion of the PC3 prostate cancer cell line as a target of miR‑155.

Chen W, He L, Liang Y, Zeng X, Wu C, Su M Mol Med Rep. 2020; 22(6):5209-5218.

PMID: 33174061 PMC: 7646979. DOI: 10.3892/mmr.2020.11623.

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