Prevention of Gallstone Recurrence by Non-steroidal Anti-inflammatory Drugs

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1988 Nov 26

PMID 2903955

Citations 20

Authors

K Hood

D Gleeson

D C Ruppin

R H Dowling

Affiliations

Soon will be listed here.

Abstract

In laboratory animals, non-steroidal anti-inflammatory drugs (NSAIDs) are reported to inhibit diet-induced gallstone formation. To see if these drugs had a similar effect in man, 82 patients who had taken part in a comparison of ursodeoxycholic acid, placebo, and diet for prevention of gallstone recurrence were sent questionnaires about their use of NSAIDs during the period of the trial. 75 replied. After a mean follow-up of 33 (SEM 4) months none of the 12 regular users of NSAIDs had had gallstone recurrences, compared with 20 of the 63 who never or rarely used these drugs (p less than 0.02).

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