MiR-1 Suppresses the Proliferation and Promotes the Apoptosis of Esophageal Carcinoma Cells by Targeting Src

Overview

Journal Cancer Med

Specialty Oncology

Date 2017 Oct 17

PMID 29034995

Citations 7

Authors

Zhicong Liao

Xiaojun Wang

Hongwei Liang

Ao Yu

Uzair Ur Rehman

Qian Fan

Yue Hu

Chen Wang

Zhen Zhou

Tao Wang

Affiliations

Soon will be listed here.

Abstract

Nonreceptor tyrosine kinase c-Src, also known as Src, is a potent oncogene involved in a series of biological processes including cell growth, differentiation, and apoptosis; however, its expression pattern and function in esophageal cancer is poorly addressed. In this study, abnormal overexpression of Src protein was observed in esophageal cancer tissues, which fuelled the speculation that microRNA-mediated posttranscriptional regulatory mechanism might be involved. Bioinformatic analyses were applied to identify miRNAs that could potentially target Src. miR-1 was predicted and further validated as a direct repressor of Src. Moreover, we manipulated knockdown and overexpression experiment on TE-1 and TE-10 cells to demonstrate miR-1 suppressed proliferation and promoted apoptosis in esophageal cancer cells by inhibiting Src. Taken together, this study underlines a negative regulatory mechanism in which miR-1 serves as a suppressor of Src in esophageal cancer cells and may provide insights into novel therapeutic approaches for esophageal cancer.

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