Na1.8 Neurons Are Involved in Limiting Acute Phase Responses to Dietary Fat

Overview

Journal Mol Metab

Specialty Cell Biology

Date 2017 Oct 17

PMID 29031710

Citations 13

Authors

Swalpa Udit

Michael Burton

Joseph M Rutkowski

Syann Lee

Angie L Bookout

Philipp E Scherer

Joel K Elmquist

Laurent Gautron

Affiliations

Soon will be listed here.

Abstract

Objective And Methods: Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Na1.8-expressing primary afferent neurons.

Results: While mice lacking sensory neurons displayed no differences in body weight, food intake, energy expenditure, or body composition compared to controls on chow diet, ablated mice developed an exaggerated inflammatory response to high-fat feeding characterized by bouts of weight loss, splenomegaly, elevated circulating interleukin-6 and hepatic serum amyloid A expression. This phenotype appeared to be directly mediated by the ingestion of saturated lipids.

Conclusions: These data demonstrate that the Na1.8-expressing afferent neurons are not essential for energy balance but are required for limiting the acute phase response caused by an obesogenic diet.

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