» Articles » PMID: 29030809

Molecular Regulation of Cellular Quiescence: A Perspective from Adult Stem Cells and Its Niches

Overview
Specialty Molecular Biology
Date 2017 Oct 15
PMID 29030809
Citations 21
Authors
Affiliations
Soon will be listed here.
Abstract

Cellular quiescence is a reversible growth arrest state. In response to extracellular environment, quiescent cells are capable of resuming proliferation for tissue homeostasis and tissue regeneration. Subpopulations of adult stem cells remain quiescent and reside in their specialized stem cell niches. Within the niche, they interact with a repertoire of niche components. Niche integrates signals to maintain quiescence or gear stem cells toward regeneration. Recent studies provide insights into the regulatory components of stem cell niche and their influence on residing stem cells. Aberrant niche activities perturb stem cell quiescence and activation, compromise stem cell functions, and contribute to tissue aging and disease pathogenesis. This review covers current knowledge regarding cellular quiescence with a focus on original and emerging concepts of how niches influence stem cell quiescence.

Citing Articles

Discovery of CTSK+ Periosteal Stem Cells Mediating Bone Repair in Orbital Reconstruction.

Liu Z, Liu J, Li J, Li Y, Sun J, Deng Y Invest Ophthalmol Vis Sci. 2023; 64(11):30.

PMID: 37639249 PMC: 10461643. DOI: 10.1167/iovs.64.11.30.


Neural, adipocyte and hepatic differentiation potential of primary and secondary hair follicle stem cells isolated from Arbas Cashmere goats.

Yan W, Hao F, Zhe X, Wang Y, Liu D BMC Vet Res. 2022; 18(1):313.

PMID: 35971123 PMC: 9377108. DOI: 10.1186/s12917-022-03420-3.


ATR activity controls stem cell quiescence via the cyclin F-SCF complex.

Salvi J, Kang J, Kim S, Colville A, de Morree A, Billeskov T Proc Natl Acad Sci U S A. 2022; 119(18):e2115638119.

PMID: 35476521 PMC: 9170012. DOI: 10.1073/pnas.2115638119.


Differential Oxygen Exposure Modulates Mesenchymal Stem Cell Metabolism and Proliferation through mTOR Signaling.

Moniz I, Ramalho-Santos J, Branco A Int J Mol Sci. 2022; 23(7).

PMID: 35409106 PMC: 8998189. DOI: 10.3390/ijms23073749.


Vaccinia Virus Arrests and Shifts the Cell Cycle.

Martin C, Samolej J, Olson A, Bertoli C, Wiebe M, de Bruin R Viruses. 2022; 14(2).

PMID: 35216024 PMC: 8874441. DOI: 10.3390/v14020431.