Immature Platelet Fraction (IPF) As a Predictive Value for Thrombopoietic Recovery After Allogeneic Stem Cell Transplantation

Overview

Journal Int J Hematol

Specialty Hematology

Date 2017 Oct 14

PMID 29027117

Citations 3

Authors

Mikiko Sakuragi

Satoru Hayashi

Miho Maruyama

Tomoko Kiyokawa

Keisuke Nagamine

Jiro Fujita

Tetsuo Maeda

Hisashi Kato

Hirokazu Kashiwagi

Yuzuru Kanakura

Yoshiaki Tomiyama

Affiliations

Soon will be listed here.

Abstract

We consecutively examined the utility of measurements of percentage of immature platelet fraction (IPF%) and absolute IPF number (A-IPF) in predicting thrombopoietic recovery in 15 adult patients who underwent allogeneic hematopoietic stem cell transplantation (allo-SCT). Four patients were excluded from the evaluation due to insufficient data. Platelet count and IPF were measured by Sysmex XN-1000 (XN), a newer generation analyzer. First, we confirmed that platelet count measured by XN was more accurate than by XE-2100 (XE). IPF measurement was effective to predict the recovery in 7 of the 11 patients examined. Moreover, IPF measurement, especially IPF% measurement, suggested accelerated platelet turnover in two patients who failed to achieve platelet recovery by day 60. In addition to IPF%, A-IPF showed a complementary role on the prediction of thrombopoietic recovery. The increase in IPF% was only transient, while A-IPF values showed lasting increase during platelet recovery. In two patients (cases 6 and 7) an increase in A-IPF, but not in IPF%, was observed during platelet recovery. Our data suggest that IPF% and A-IPF measured by XN are useful for the prediction of thrombopoietic recovery and the assessment of pathogenesis of thrombocytopenia in patients after allo-SCT.

Citing Articles

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Immature Platelet Fraction: Its Clinical Utility in Thrombocytopenia Patients.

Goel G, Semwal S, Khare A, Joshi D, Amerneni C, Pakhare A J Lab Physicians. 2021; 13(3):214-218.

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Assessment of haematopoietic progenitor cell counting with the Sysmex XN-1000 to guide timing of apheresis of peripheral blood stem cells.

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