Reticulated Platelet Monitoring After Autologous Peripheral Haematopoietic Progenitor Cell Transplantation

Overview

Journal Transfus Apher Sci

Specialty Hematology

Date 2009 Apr 29

PMID 19398373

Citations 3

Authors

Giovanna Martinelli

Patrizia Merlo

Rita Fantasia

Francesco Gioia

Giovanni Crovetti

Affiliations

Soon will be listed here.

Abstract

Reticulated platelets are the youngest marker of megakaryopoiesis. We monitored 13 haematological patients undergoing autologous peripheral haematopoietic progenitor cell transplantation. We used a flow cytometric method based on thiazole orange platelet staining. Patients showed a fall in reticulated platelet percentage at a mean of 5 days before a nadir of the platelet count. In all cases, platelet recovery is preceded by a rise of reticulated platelets; in 10 cases patients received platelet prophylactic transfusions after RP rise. The rise in reticulated platelets is an early sign of engraftment and may represent an easy parameter for transfusion management of transplanted patients.

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Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation.

van der Linden N, Klinkenberg L, Meex S, Beckers E, de Wit N, Prinzen L Eur J Haematol. 2014; 93(2):150-6.

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