PTEN Drives Th17 Cell Differentiation by Preventing IL-2 Production

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2017 Oct 12

PMID 29018045

Citations 35

Authors

Hyeong Su Kim

Sung Woong Jang

Wonyong Lee

Kiwan Kim

Hyogon Sohn

Soo Seok Hwang

Gap Ryol Lee

Affiliations

Soon will be listed here.

Abstract

T helper 17 (Th17) cells are a CD4 T cell subset that produces IL-17A to mediate inflammation and autoimmunity. IL-2 inhibits Th17 cell differentiation. However, the mechanism by which IL-2 is suppressed during Th17 cell differentiation remains unclear. Here, we show that phosphatase and tensin homologue (PTEN) is a key factor that regulates Th17 cell differentiation by suppressing IL-2 production. Th17-specific deletion ( ) impairs Th17 cell differentiation in vitro and ameliorated symptoms of experimental autoimmune encephalomyelitis (EAE), a model of Th17-mediated autoimmune disease. Mechanistically, deficiency up-regulates IL-2 and phosphorylation of STAT5, but reduces STAT3 phosphorylation, thereby inhibiting Th17 cell differentiation. PTEN inhibitors block Th17 cell differentiation in vitro and in the EAE model. Thus, PTEN plays a key role in Th17 cell differentiation by blocking IL-2 expression.

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