Species Infecting Children Presenting with Malaria in Uganda

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2017 Oct 10

PMID 28990911

Citations 24

Authors

Victor Asua

Stephen Tukwasibwe

Melissa Conrad

Andrew Walakira

Joaniter I Nankabirwa

Levicatus Mugenyi

Moses R Kamya

Samuel L Nsobya

Philip J Rosenthal

Affiliations

Soon will be listed here.

Abstract

Contributions of species other than to human malaria in sub-Saharan Africa are uncertain. We collected blood from children aged 6 months to 10 years diagnosed with malaria by Giemsa-stained blood smears (176 subjects) or histidine rich protein-2-based rapid diagnostic tests (323 subjects) in 2016; 50 samples from each of 10 sites across Uganda were studied to identify infecting species. Of 499 available samples, 474 demonstrated plasmodial infection by polymerase chain reaction amplification of 18S ribosomal RNA genes, including in 472, in 22, in 15, and in four; 435 were pure , two did not contain , and the remainder were mixed infections including . The prevalence of nonfalciparum species varied geographically. Stratifying based on recent history of indoor residual spraying (IRS) of insecticides, nonfalciparum infections were seen in 27/189 (14.8%) samples from sites that received and 13/285 (4.6%) samples from sites that did not receive IRS since 2010 ( = 0.0013). Overall, 39/474 (8.2%) samples from individuals diagnosed with malaria included nonfalciparum infections. Thus, a substantial proportion of episodes of malaria in Uganda include infections with plasmodial species other than .

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