GRHL2 Suppresses Tumor Metastasis Via Regulation of Transcriptional Activity of RhoG in Non-small Cell Lung Cancer

Overview

Journal Am J Transl Res

Specialty General Medicine

Date 2017 Oct 6

PMID 28979695

Citations 17

Authors

Xiang Pan

Rong Zhang

Caifeng Xie

Mingxi Gan

Sheng Yao

Yubin Yao

Jiangbo Jin

Tianyu Han

Yunhe Huang

Yanlong Gong

Jianbin Wang

Bentong Yu

Affiliations

Soon will be listed here.

Abstract

The transcription factor, Grainyhead-like 2 (GRHL2), is involved in wound healing, epidermal integrity, and epithelial-to-mesenchymal transition (EMT) in various biological processes; however, the biological function of GRHL2 in non-small cell lung cancer (NSCLC) is unknown. In the current study, we investigated the effect of GRHL2 on cell growth and migration in NSCLC cell lines and clinical tissues. Immunohistochemical analysis of clinical NSCLC specimens revealed that patients with high GRHL2 expression were associated with poor prognosis compared to patients with low GRHL2 expression. GRHL2 overexpression promoted cell growth and colony formation, and simultaneously suppressed cell migration in NSCLC cells. Furthermore, GRHL2 decreased the transcriptional activity of RhoG by directly binding to the RhoG promoter region. These findings confirm that GRHL2 plays an important role in regulating cell proliferation and migration in NSCLC.

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