Grainyhead-like Transcription Factors in Cancer - Focus on Recent Developments

Overview

Journal Exp Biol Med (Maywood)

Specialty Biology

Date 2020 Feb 4

PMID 32008358

Citations 11

Authors

Grzegorz Kotarba

Agnieszka Taracha-Wisniewska

Tomasz Wilanowski

Affiliations

Soon will be listed here.

Citing Articles

GRHL2-HER3 and E-cadherin mediate EGFR-bypass drug resistance in lung cancer cells.

Ito F, Iwata W, Adachi Y, Sesaki H, Iijima M Front Cell Dev Biol. 2025; 12:1511190.

PMID: 39897079 PMC: 11782226. DOI: 10.3389/fcell.2024.1511190.

ZNF217 Mediates Transcriptional Activation of GRHL3 to Regulate SLC22A31 and Promote Malignant Progression in Thyroid Cancer.

Xu Y, Liu C, Meng Q Mol Biotechnol. 2024; .

PMID: 39354204 DOI: 10.1007/s12033-024-01292-6.

Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence.

MacFawn I, Farris J, Pifer P, Margaryan N, Akhter H, Wang L Mol Immunol. 2024; 170:156-169.

PMID: 38692097 PMC: 11106721. DOI: 10.1016/j.molimm.2024.04.012.

Exploration of the Correlation Between Expression and Tumor Microenvironment in Endometrial Cancer and Immunotherapy.

Guo S, Bai W, Cui F, Chen X, Fang X, Shen H Pharmgenomics Pers Med. 2024; 17:91-103.

PMID: 38586176 PMC: 10999208. DOI: 10.2147/PGPM.S453061.

Dual role of GRHL3 in bladder carcinogenesis depending on histological subtypes.

Lammert F, Pannhausen J, Noetzel E, Friedland F, Wirtz J, Herfs Y Mol Oncol. 2024; 18(6):1397-1416.

PMID: 38429970 PMC: 11164254. DOI: 10.1002/1878-0261.13623.

References

Pawlak M, Kikulska A, Wrzesinski T, Rausch T, Kwias Z, Wilczynski B . Potential protective role of Grainyhead-like genes in the development of clear cell renal cell carcinoma. Mol Carcinog. 2017; 56(11):2414-2423. DOI: 10.1002/mc.22682. View

Auden A, Caddy J, Wilanowski T, Ting S, Cunningham J, Jane S . Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development. Gene Expr Patterns. 2006; 6(8):964-70. DOI: 10.1016/j.modgep.2006.03.011. View

Hu F, He Z, Sun C, Rong D . Knockdown of GRHL2 inhibited proliferation and induced apoptosis of colorectal cancer by suppressing the PI3K/Akt pathway. Gene. 2019; 700:96-104. DOI: 10.1016/j.gene.2019.03.051. View

Kikulska A, Rausch T, Krzywinska E, Pawlak M, Wilczynski B, Benes V . Coordinated expression and genetic polymorphisms in Grainyhead-like genes in human non-melanoma skin cancers. BMC Cancer. 2018; 18(1):23. PMC: 5755140. DOI: 10.1186/s12885-017-3943-8. View

Santos R, Ursu O, Gaulton A, Bento A, Donadi R, Bologa C . A comprehensive map of molecular drug targets. Nat Rev Drug Discov. 2016; 16(1):19-34. PMC: 6314433. DOI: 10.1038/nrd.2016.230. View

Han B, Yang X, Li Y, Hosseini D, Tu Y, Dong Y . Association of polymorphisms in grainyhead-like-2 gene with the susceptibility to age-related hearing loss: A systematic review and meta-analysis. Medicine (Baltimore). 2019; 98(25):e16128. PMC: 6636934. DOI: 10.1097/MD.0000000000016128. View

Nishino H, Takano S, Yoshitomi H, Suzuki K, Kagawa S, Shimazaki R . Grainyhead-like 2 (GRHL2) regulates epithelial plasticity in pancreatic cancer progression. Cancer Med. 2017; 6(11):2686-2696. PMC: 5673909. DOI: 10.1002/cam4.1212. View

Reese R, Harrison M, Alarid E . Grainyhead-like Protein 2: The Emerging Role in Hormone-Dependent Cancers and Epigenetics. Endocrinology. 2019; 160(5):1275-1288. DOI: 10.1210/en.2019-00213. View

Fabian J, Lodrini M, Oehme I, Schier M, Thole T, Hielscher T . GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3. Cancer Res. 2014; 74(9):2604-16. DOI: 10.1158/0008-5472.CAN-13-1904. View

10.

Tam V, Patel N, Turcotte M, Bosse Y, Pare G, Meyre D . Benefits and limitations of genome-wide association studies. Nat Rev Genet. 2019; 20(8):467-484. DOI: 10.1038/s41576-019-0127-1. View

11.

Quan Y, Jin R, Huang A, Zhao H, Feng B, Zang L . Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1. Cancer Biol Ther. 2014; 15(7):878-87. PMC: 4100988. DOI: 10.4161/cbt.28877. View

12.

Mlacki M, Kikulska A, Krzywinska E, Pawlak M, Wilanowski T . Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer. Exp Biol Med (Maywood). 2015; 240(11):1396-401. PMC: 4935299. DOI: 10.1177/1535370215588924. View

13.

Riethdorf S, Frey S, Santjer S, Stoupiec M, Otto B, Riethdorf L . Diverse expression patterns of the EMT suppressor grainyhead-like 2 (GRHL2) in normal and tumour tissues. Int J Cancer. 2015; 138(4):949-63. DOI: 10.1002/ijc.29841. View

14.

Kang X, Chen W, Kim R, Kang M, Park N . Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells. Oncogene. 2008; 28(4):565-74. PMC: 2919678. DOI: 10.1038/onc.2008.404. View

15.

Yang Z, Wu D, Chen Y, Min Z, Quan Y . GRHL2 inhibits colorectal cancer progression and metastasis via oppressing epithelial-mesenchymal transition. Cancer Biol Ther. 2019; 20(9):1195-1205. PMC: 6741563. DOI: 10.1080/15384047.2019.1599664. View

16.

Krzywinska E, Zorawski M, Taracha A, Kotarba G, Kikulska A, Mlacki M . Threonine 454 phosphorylation in Grainyhead-like 3 is important for its function and regulation by the p38 MAPK pathway. Biochim Biophys Acta Mol Cell Res. 2018; 1865(7):1002-1011. DOI: 10.1016/j.bbamcr.2018.04.010. View

17.

Nusslein-Volhard C, Wieschaus E, Kluding H . Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster : I. Zygotic loci on the second chromosome. Wilehm Roux Arch Dev Biol. 2017; 193(5):267-282. DOI: 10.1007/BF00848156. View

18.

Leslie E, Liu H, Carlson J, Shaffer J, Feingold E, Wehby G . A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3. Am J Hum Genet. 2016; 98(4):744-54. PMC: 4833215. DOI: 10.1016/j.ajhg.2016.02.014. View

19.

Chen W, Yi J, Shimane T, Mehrazarin S, Lin Y, Shin K . Grainyhead-like 2 regulates epithelial plasticity and stemness in oral cancer cells. Carcinogenesis. 2016; 37(5):500-10. PMC: 6118232. DOI: 10.1093/carcin/bgw027. View

20.

Hornbeck P, Zhang B, Murray B, Kornhauser J, Latham V, Skrzypek E . PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Nucleic Acids Res. 2014; 43(Database issue):D512-20. PMC: 4383998. DOI: 10.1093/nar/gku1267. View