Biased Usage of Certain Vk Gene Families by Autoantibodies and Their Polymorphism in Autoimmune Mice

Overview

Journal Mol Immunol

Specialties Allergy & Immunology
Molecular Biology

Date 1988 Feb 1

PMID 2897624

Citations 8

Authors

K Kasturi

M Monestier

R Mayer

C Bona

Affiliations

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Abstract

Of 79 hybridomas derived from stimulated or unstimulated autoimmune disease prone mouse strains, secreting autoantibodies of various specificities more than 65% use V genes from five Vk families, namely, Vk1, Vk4, Vk8, Vk10 and Vk19. Restriction fragment length polymorphism (RFLP) analysis of genomic DNAs from autoimmune prone mouse strains, tight skin, NZB and SJL show marked differences in the polymorphism of the Vk1, Vk10 and Vk19 gene families.

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