Bridge Between Type 1 Diabetes in Mouse and Man

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2017 Oct 5

PMID 28973949

Citations 4

Authors

Defu Zeng

Affiliations

Soon will be listed here.

Citing Articles

Rational Engineering of Islet Tolerance via Biomaterial-Mediated Immune Modulation.

Klug N, Burke J, Scott E J Immunol. 2024; 212(2):216-224.

PMID: 38166244 PMC: 10766078. DOI: 10.4049/jimmunol.2300527.

T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice.

Vecchione A, Madley R, Danzl N, Borsotti C, Marharlooei M, Li H Clin Immunol. 2022; 240:109048.

PMID: 35644520 PMC: 9564152. DOI: 10.1016/j.clim.2022.109048.

Haploidentical mixed chimerism cures autoimmunity in established type 1 diabetic mice.

Liu Y, Wang X, Zhu Y, Zhang M, Nasri U, Sun S J Clin Invest. 2020; 130(12):6457-6476.

PMID: 32817590 PMC: 7685732. DOI: 10.1172/JCI131799.

MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice.

Zhang M, Racine J, Lin Q, Liu Y, Tang S, Qin Q Proc Natl Acad Sci U S A. 2018; 115(10):E2329-E2337.

PMID: 29463744 PMC: 5877958. DOI: 10.1073/pnas.1720169115.

References

Tary-Lehmann M, Saxon A . Human mature T cells that are anergic in vivo prevail in SCID mice reconstituted with human peripheral blood. J Exp Med. 1992; 175(2):503-16. PMC: 2119121. DOI: 10.1084/jem.175.2.503. View

Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D . Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature. 2005; 435(7039):220-3. PMC: 1364531. DOI: 10.1038/nature03523. View

Aly T, Ide A, Jahromi M, Barker J, Fernando M, Babu S . Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A. 2006; 103(38):14074-9. PMC: 1563993. DOI: 10.1073/pnas.0606349103. View

Krishnamurthy B, Dudek N, McKenzie M, Purcell A, Brooks A, Gellert S . Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest. 2006; 116(12):3258-65. PMC: 1679712. DOI: 10.1172/JCI29602. View

Shultz L, Ishikawa F, Greiner D . Humanized mice in translational biomedical research. Nat Rev Immunol. 2007; 7(2):118-30. DOI: 10.1038/nri2017. View

Nejentsev S, Howson J, Walker N, Szeszko J, Field S, Stevens H . Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature. 2007; 450(7171):887-92. PMC: 2703779. DOI: 10.1038/nature06406. View

Santamaria P . The long and winding road to understanding and conquering type 1 diabetes. Immunity. 2010; 32(4):437-45. DOI: 10.1016/j.immuni.2010.04.003. View

Coppieters K, Dotta F, Amirian N, Campbell P, Kay T, Atkinson M . Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med. 2012; 209(1):51-60. PMC: 3260877. DOI: 10.1084/jem.20111187. View

Roep B, Buckner J, Sawcer S, Toes R, Zipp F . The problems and promises of research into human immunology and autoimmune disease. Nat Med. 2012; 18(1):48-53. DOI: 10.1038/nm.2626. View

10.

Atkinson M, Eisenbarth G, Michels A . Type 1 diabetes. Lancet. 2013; 383(9911):69-82. PMC: 4380133. DOI: 10.1016/S0140-6736(13)60591-7. View

11.

Mohan J, Calderon B, Anderson M, Unanue E . Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes. J Exp Med. 2013; 210(11):2403-14. PMC: 3804950. DOI: 10.1084/jem.20130582. View

12.

Viehmann Milam A, Maher S, Gibson J, Lebastchi J, Wen L, Ruddle N . A humanized mouse model of autoimmune insulitis. Diabetes. 2014; 63(5):1712-24. PMC: 3994947. DOI: 10.2337/db13-1141. View

13.

Ko H, Chee J, Sutherland R, Thomas H, Zhan Y, Krishnamurthy B . Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse. Immunol Cell Biol. 2014; 92(7):640-4. DOI: 10.1038/icb.2014.29. View

14.

Pearson J, Wong F, Wen L . The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes. J Autoimmun. 2015; 66:76-88. PMC: 4765310. DOI: 10.1016/j.jaut.2015.08.019. View

15.

Delong T, Wiles T, Baker R, Bradley B, Barbour G, Reisdorph R . Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion. Science. 2016; 351(6274):711-4. PMC: 4884646. DOI: 10.1126/science.aad2791. View

16.

Kracht M, van Lummel M, Nikolic T, Joosten A, Laban S, van der Slik A . Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes. Nat Med. 2017; 23(4):501-507. DOI: 10.1038/nm.4289. View

17.

Tan S, Li Y, Xia J, Jin C, Hu Z, Duinkerken G . Type 1 diabetes induction in humanized mice. Proc Natl Acad Sci U S A. 2017; 114(41):10954-10959. PMC: 5642714. DOI: 10.1073/pnas.1710415114. View

18.

Hattori M, Buse J, Jackson R, Glimcher L, Dorf M, Minami M . The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science. 1986; 231(4739):733-5. DOI: 10.1126/science.3003909. View

19.

Wong F, Visintin I, Wen L, Flavell R, Janeway Jr C . CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med. 1996; 183(1):67-76. PMC: 2192404. DOI: 10.1084/jem.183.1.67. View

20.

Wen L, Wong F, Burkly L, Altieri M, Mamalaki C, Kioussis D . Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. J Clin Invest. 1998; 102(5):947-57. PMC: 508960. DOI: 10.1172/JCI2723. View