Challenges of the Nano-Bio Interface in Lateral Flow and Dipstick Immunoassays

Overview

Journal Trends Biotechnol

Specialty Biochemistry

Date 2017 Oct 3

PMID 28965747

Citations 34

Authors

Helena de Puig

Irene Bosch

Lee Gehrke

Kimberly Hamad-Schifferli

Affiliations

Soon will be listed here.

Abstract

Lateral flow assays (LFAs) are highly attractive for point-of-care (POC) diagnostics for infectious disease, food safety, and many other medical uses. The unique optical, electronic, and chemical properties that arise from the nanostructured and material characteristics of nanoparticles provide an opportunity to increase LFA sensitivity and impart novel capabilities. However, interfacing to nanomaterials in complex biological environments is challenging and can result in undesirable side effects such as non-specific adsorption, protein denaturation, and steric hindrance. These issues are even more acute in LFAs where there are many different types of inorganic-biological interfaces, often of a complex nature. Therefore, the unique properties of nanomaterials for LFAs must be exploited in a way that addresses these interface challenges.

Citing Articles

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