Overuse Syndrome: a Muscle Biopsy Study

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1988 Apr 23

PMID 2895831

Citations 20

Authors

X Dennett

H J Fry

Affiliations

Soon will be listed here.

Abstract

Biopsy specimens were taken from the affected first dorsal interosseous muscle in 29 women with painful chronic overuse syndrome and from 8 volunteer controls. Structural differences in samples from the women with overuse syndrome included increased type 1 fibres with type grouping, decreased type 2 fibres, type 2 fibre hypertrophy, increased internal nuclear count, mitochondrial changes, and various ultrastructural abnormalities. These changes were related to clinical severity, and point to an organic cause for the syndrome.

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Blocking substance P signaling reduces musculotendinous and dermal fibrosis and sensorimotor declines in a rat model of overuse injury.

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Increased serum and musculotendinous fibrogenic proteins following persistent low-grade inflammation in a rat model of long-term upper extremity overuse.

Gao H, Fisher P, Lambi A, Wade C, Barr-Gillespie A, Popoff S PLoS One. 2013; 8(8):e71875.

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