Ocular Surface Inflammation Impairs Structure and Function of Meibomian Gland

Overview

Journal Exp Eye Res

Specialty Ophthalmology

Date 2017 Sep 28

PMID 28950941

Citations 23

Authors

Shin Mizoguchi

Hiroki Iwanishi

Reiko Arita

Kumi Shirai

Takayoshi Sumioka

Masahide Kokado

James V Jester

Shizuya Saika

Affiliations

Soon will be listed here.

Abstract

Dysfunction of the meibomian glands alters secreted meibum quantitatively and qualitatively that can lead to damage to the ocular surface epithelium. In response to an unstable tear film cause by meibomian gland dysfunction, ocular surface epithelium is damaged and expresses inflammatory cytokines leading to secondary ocular inflammation. In turn, inflammatory disorders of the palpebral conjunctiva and lid margin may affect the structure and function of meibomian gland. The disorders include allergic conjunctivitis, long-term usage of contact lenses, dermatological diseases that affect conjunctival homeostasis, Stevens-Johnson's syndrome or chemical burning of the ocular surface and lid margin.

Citing Articles

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Meibomian gland alterations in allergic conjunctivitis: insights from a novel quantitative analysis algorithm.

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Higher incidence of meibomian gland dysfunction in postmenopausal women with primary acquired nasolacrimal duct obstruction.

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