The Versatile Effects of Dihydromyricetin in Health

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2017 Sep 27

PMID 28947908

Citations 37

Authors

Hongliang Li

Qisheng Li

Zhaowen Liu

Kai Yang

Zhixi Chen

Qilai Cheng

Longhuo Wu

Affiliations

Soon will be listed here.

Abstract

Dihydromyricetin is a flavonoid isolated from , which is traditionally used in China. Dihydromyricetin exhibits health-benefiting activities with minimum adverse effects. Dihydromyricetin has been demonstrated to show antioxidative, anti-inflammatory, anticancer, antimicrobial, cell death-mediating, and lipid and glucose metabolism-regulatory activities. Dihydromyricetin may scavenge ROS to protect against oxidative stress or potentiate ROS generation to counteract cancer cells selectively without any effects on normal cells. However, the low bioavailability of dihydromyricetin limits its potential applications. Recent research has gained positive and promising data. This review will discuss the versatile effects and clinical prospective of dihydromyricetin.

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References

Liu L, Yin X, Wang X, Li X . Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Pharm Biol. 2016; 55(1):657-662. PMC: 6130699. DOI: 10.1080/13880209.2016.1266669. View

Xia J, Guo S, Fang T, Feng D, Zhang X, Zhang Q . Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways. Food Chem Toxicol. 2014; 66:7-13. DOI: 10.1016/j.fct.2014.01.014. View

Zhu H, Luo P, Fu Y, Wang J, Dai J, Shao J . Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin. Oncotarget. 2014; 6(5):3254-67. PMC: 4413651. DOI: 10.18632/oncotarget.2410. View

Huang H, Liao C, Peng C, Lim J, Siao J, Wei C . Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways. Chem Biol Interact. 2016; 258:166-74. DOI: 10.1016/j.cbi.2016.08.023. View

Williams J, Ensor C, Gardner S, Smith R, Lodder R . BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet. Webmedcentral. 2016; 6(12). PMC: 5036941. View

Huang H, Hu M, Zhao R, Li P, Li M . Dihydromyricetin suppresses the proliferation of hepatocellular carcinoma cells by inducing G2/M arrest through the Chk1/Chk2/Cdc25C pathway. Oncol Rep. 2013; 30(5):2467-75. DOI: 10.3892/or.2013.2705. View

Xie C, Chen Z, Zhang C, Xu X, Jin J, Zhan W . Dihydromyricetin ameliorates oleic acid-induced lipid accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress. Life Sci. 2016; 157:131-139. DOI: 10.1016/j.lfs.2016.06.001. View

Wu F, Li Y, Song H, Zhang Y, Zhang Y, Jiang M . Preventive Effect of Dihydromyricetin against Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo. Evid Based Complement Alternat Med. 2016; 2016:7937385. PMC: 5013228. DOI: 10.1155/2016/7937385. View

Liu B, Zhou W, Chen X, Xu F, Chen Y, Liu J . Dihydromyricetin induces mouse hepatoma Hepal-6 cell apoptosis via the transforming growth factor-β pathway. Mol Med Rep. 2014; 11(3):1609-14. PMC: 4270327. DOI: 10.3892/mmr.2014.2891. View

10.

Liu S, Ai Q, Feng K, Li Y, Liu X . The cardioprotective effect of dihydromyricetin prevents ischemia-reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1α signaling pathways. Apoptosis. 2016; 21(12):1366-1385. DOI: 10.1007/s10495-016-1306-6. View

11.

Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E . Effect of dihydromyricetin on benzo[a]pyrene activation in rats. Neuro Endocrinol Lett. 2015; 35 Suppl 2:158-68. View

12.

Fan T, Wu T, Bu L, Ma S, Li Y, Mao L . Dihydromyricetin promotes autophagy and apoptosis through ROS-STAT3 signaling in head and neck squamous cell carcinoma. Oncotarget. 2016; 7(37):59691-59703. PMC: 5312341. DOI: 10.18632/oncotarget.10836. View

13.

Liang J, Olsen R . Alcohol use disorders and current pharmacological therapies: the role of GABA(A) receptors. Acta Pharmacol Sin. 2014; 35(8):981-93. PMC: 4125717. DOI: 10.1038/aps.2014.50. View

14.

Zhou D, Sun H, Yue J, Peng Y, Chen Y, Zhong Z . Dihydromyricetin induces apoptosis and cytoprotective autophagy through ROS-NF-κB signalling in human melanoma cells. Free Radic Res. 2017; 51(5):517-528. DOI: 10.1080/10715762.2017.1328552. View

15.

Liu T, Zeng Y, Tang K, Chen X, Zhang W, Le Xu X . Dihydromyricetin ameliorates atherosclerosis in LDL receptor deficient mice. Atherosclerosis. 2017; 262:39-50. DOI: 10.1016/j.atherosclerosis.2017.05.003. View

16.

Li T, Wong V, Jiang Z, Jiang S, Liu Y, Wang T . Mutation of cysteine 46 in IKK-beta increases inflammatory responses. Oncotarget. 2015; 6(31):31805-19. PMC: 4741641. DOI: 10.18632/oncotarget.5567. View

17.

Ren Z, Zhao Y, Cao T, Zhen X . Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity. Acta Pharmacol Sin. 2016; 37(10):1315-1324. PMC: 5057232. DOI: 10.1038/aps.2016.42. View

18.

Liu B, Lin B, Tan X, Liang J, Wu S, Liu J . A reduction in reactive oxygen species contributes to dihydromyricetin-induced apoptosis in human hepatocellular carcinoma cells. Sci Rep. 2014; 4:7041. PMC: 4229672. DOI: 10.1038/srep07041. View

19.

Cao S, Deng X, Xu P, Huang Z, Zhou J, Li X . Highly Efficient Enzymatic Acylation of Dihydromyricetin by the Immobilized Lipase with Deep Eutectic Solvents as Cosolvent. J Agric Food Chem. 2017; 65(10):2084-2088. DOI: 10.1021/acs.jafc.7b00011. View

20.

Zhang W, Wang S, Yin H, Chen E, Xue D, Zheng Q . Dihydromyricetin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro partially via the activation of Wnt/β-catenin signaling pathway. Fundam Clin Pharmacol. 2016; 30(6):596-606. DOI: 10.1111/fcp.12225. View