Nanoscopic Control and Quantification of Enantioselective Optical Forces

Overview

Journal Nat Nanotechnol

Specialty Biotechnology

Date 2017 Sep 26

PMID 28945237

Citations 18

Authors

Yang Zhao

Amr A E Saleh

Marie Anne van de Haar

Brian Baum

Justin A Briggs

Alice Lay

Olivia A Reyes-Becerra

Jennifer A Dionne

Affiliations

Soon will be listed here.

Abstract

Circularly polarized light (CPL) exerts a force of different magnitude on left- and right-handed enantiomers, an effect that could be exploited for chiral resolution of chemical compounds as well as controlled assembly of chiral nanostructures. However, enantioselective optical forces are challenging to control and quantify because their magnitude is extremely small (sub-piconewton) and varies in space with sub-micrometre resolution. Here, we report a technique to both strengthen and visualize these forces, using a chiral atomic force microscope probe coupled to a plasmonic optical tweezer. Illumination of the plasmonic tweezer with CPL exerts a force on the microscope tip that depends on the handedness of the light and the tip. In particular, for a left-handed chiral tip, transverse forces are attractive with left-CPL and repulsive with right-CPL. Additionally, total force differences between opposite-handed specimens exceed 10 pN. The microscope tip can map chiral forces with 2 nm lateral resolution, revealing a distinct spatial distribution of forces for each handedness.

Citing Articles

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References

Tkachenko G, Brasselet E . Optofluidic sorting of material chirality by chiral light. Nat Commun. 2014; 5:3577. DOI: 10.1038/ncomms4577. View

Noorduin W, Bode A, van der Meijden M, Meekes H, van Etteger A, van Enckevort W . Complete chiral symmetry breaking of an amino acid derivative directed by circularly polarized light. Nat Chem. 2010; 1(9):729-32. DOI: 10.1038/nchem.416. View

Tang Y, Cohen A . Enhanced enantioselectivity in excitation of chiral molecules by superchiral light. Science. 2011; 332(6027):333-6. DOI: 10.1126/science.1202817. View

Roxworthy B, Bhuiya A, Vanka S, Toussaint Jr K . Understanding and controlling plasmon-induced convection. Nat Commun. 2014; 5:3173. DOI: 10.1038/ncomms4173. View

Huang F, Tamma V, Mardy Z, Burdett J, Wickramasinghe H . Imaging Nanoscale Electromagnetic Near-Field Distributions Using Optical Forces. Sci Rep. 2015; 5:10610. PMC: 5155520. DOI: 10.1038/srep10610. View

de Man S, Heeck K, Wijngaarden R, Iannuzzi D . Halving the Casimir force with conductive oxides. Phys Rev Lett. 2009; 103(4):040402. DOI: 10.1103/PhysRevLett.103.040402. View

Kuzyk A, Schreiber R, Zhang H, Govorov A, Liedl T, Liu N . Reconfigurable 3D plasmonic metamolecules. Nat Mater. 2014; 13(9):862-6. DOI: 10.1038/nmat4031. View

Shoji T, Tsuboi Y . Plasmonic Optical Tweezers toward Molecular Manipulation: Tailoring Plasmonic Nanostructure, Light Source, and Resonant Trapping. J Phys Chem Lett. 2015; 5(17):2957-67. DOI: 10.1021/jz501231h. View

Righini M, Volpe G, Girard C, Petrov D, Quidant R . Surface plasmon optical tweezers: tunable optical manipulation in the femtonewton range. Phys Rev Lett. 2008; 100(18):186804. DOI: 10.1103/PhysRevLett.100.186804. View

10.

Berthelot J, Acimovic S, Juan M, Kreuzer M, Renger J, Quidant R . Three-dimensional manipulation with scanning near-field optical nanotweezers. Nat Nanotechnol. 2014; 9(4):295-9. DOI: 10.1038/nnano.2014.24. View

11.

Lezec H, Degiron A, Devaux E, Linke R, Martin-Moreno L, Garcia-Vidal F . Beaming light from a subwavelength aperture. Science. 2002; 297(5582):820-2. DOI: 10.1126/science.1071895. View

12.

Saleh A, Sheikhoelislami S, Gastelum S, Dionne J . Grating-flanked plasmonic coaxial apertures for efficient fiber optical tweezers. Opt Express. 2016; 24(18):20593-603. DOI: 10.1364/OE.24.020593. View

13.

Munday J, Capasso F, Parsegian V . Measured long-range repulsive Casimir-Lifshitz forces. Nature. 2009; 457(7226):170-3. PMC: 4169270. DOI: 10.1038/nature07610. View

14.

Hayat A, Mueller J, Capasso F . Lateral chirality-sorting optical forces. Proc Natl Acad Sci U S A. 2015; 112(43):13190-4. PMC: 4629360. DOI: 10.1073/pnas.1516704112. View

15.

van de Haar M, Maas R, Schokker H, POLMAN A . Experimental realization of a polarization-independent ultraviolet/visible coaxial plasmonic metamaterial. Nano Lett. 2014; 14(11):6356-60. PMC: 4245717. DOI: 10.1021/nl5028183. View

16.

Wang S, Chan C . Lateral optical force on chiral particles near a surface. Nat Commun. 2014; 5:3307. PMC: 3959198. DOI: 10.1038/ncomms4307. View

17.

Nowak D, Morrison W, Wickramasinghe H, Jahng J, Potma E, Wan L . Nanoscale chemical imaging by photoinduced force microscopy. Sci Adv. 2016; 2(3):e1501571. PMC: 4820382. DOI: 10.1126/sciadv.1501571. View

18.

Bailey , Chrysostomou , Hough , Gledhill , McCall , Clark . Circular polarization in star- formation regions: implications for biomolecular homochirality . Science. 1998; 281(5377):672-4. View

19.

Rajapaksa I, Uenal K, Wickramasinghe H . Image force microscopy of molecular resonance: A microscope principle. Appl Phys Lett. 2010; 97(7). PMC: 2941516. DOI: 10.1063/1.3480608. View

20.

Cronin J, Pizzarello S . Enantiomeric excesses in meteoritic amino acids. Science. 1997; 275(5302):951-5. DOI: 10.1126/science.275.5302.951. View