Maternal Immunization with P Fimbriae for the Prevention of Neonatal Pyelonephritis

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1988 Jan 1

PMID 2891616

Citations 10

Authors

M B Kaack

J A Roberts

G Baskin

G M Patterson

Affiliations

Soon will be listed here.

Abstract

Rhesus monkeys (Macaca mulatta) were immunized with purified P fimbriae from Escherichia coli during the last trimester of pregnancy. Infants born of these mothers were compared with those from nonimmunized rhesus mothers. A delay in the onset of renal disease after bladder infection showed protection from passive immunization. This was associated with a high antibody titer in serum. In addition to delayed onset of renal infection, a decreased number of immunized monkeys developed pyelonephritis.

Citing Articles

Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections.

OBrien V, Hannan T, Nielsen H, Hultgren S Microbiol Spectr. 2016; 4(1).

PMID: 26999391 PMC: 4887100. DOI: 10.1128/microbiolspec.UTI-0013-2012.

Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein.

Roberts J, Kaack M, Baskin G, Chapman M, Hunstad D, Pinkner J J Urol. 2004; 171(4):1682-5.

PMID: 15017266 PMC: 2838480. DOI: 10.1097/01.ju.0000116123.05160.43.

Analysis of the F antigen-specific papA alleles of extraintestinal pathogenic Escherichia coli using a novel multiplex PCR-based assay.

Johnson J, Stell A, Scheutz F, OBryan T, Russo T, Carlino U Infect Immun. 2000; 68(3):1587-99.

PMID: 10678978 PMC: 97319. DOI: 10.1128/IAI.68.3.1587-1599.2000.

Prevention of renal scarring from pyelonephritis in nonhuman primates by vaccination with a synthetic Escherichia coli serotype O8 oligosaccharide-protein conjugate.

Roberts J, Kaack M, Baskin G, Svenson S Infect Immun. 1993; 61(12):5214-8.

PMID: 8225595 PMC: 281303. DOI: 10.1128/iai.61.12.5214-5218.1993.

The PapG tip adhesin of P fimbriae protects Escherichia coli from neutrophil bactericidal activity.

Tewari R, Ikeda T, Malaviya R, Macgregor J, Little J, Hultgren S Infect Immun. 1994; 62(12):5296-304.

PMID: 7960108 PMC: 303268. DOI: 10.1128/iai.62.12.5296-5304.1994.

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