The Lipid Droplet: A Conserved Cellular Organelle

Overview

Journal Protein Cell

Publisher Oxford University Press

Specialties Biochemistry
Cell Biology

Date 2017 Sep 16

PMID 28913786

Citations 30

Authors

Congyan Zhang

Pingsheng Liu

Affiliations

Soon will be listed here.

Abstract

The lipid droplet (LD) is a unique multi-functional organelle that contains a neutral lipid core covered with a phospholipid monolayer membrane. The LDs have been found in almost all organisms from bacteria to humans with similar shape. Several conserved functions of LDs have been revealed by recent studies, including lipid metabolism and trafficking, as well as nucleic acid binding and protection. We summarized these findings and proposed a hypothesis that the LD is a conserved organelle.

Citing Articles

A fluorescence lifetime-based novel method for accurate lipid quantification of BODIPY vital-stained C. elegans.

Xu C, Luo J, Yu Y J Lipid Res. 2024; 65(10):100646.

PMID: 39303981 PMC: 11530801. DOI: 10.1016/j.jlr.2024.100646.

Delta-6 desaturase FADS2 is a tumor-promoting factor in cholangiocarcinoma.

Hasegawa K, Fujimori H, Nakatani K, Takahashi M, Izumi Y, Bamba T Cancer Sci. 2024; 115(10):3346-3357.

PMID: 39113435 PMC: 11447924. DOI: 10.1111/cas.16306.

Genome-wide identification and evolution of the tubulin gene family in Camelina sativa.

Blume R, Rabokon A, Pydiura M, Yemets A, Pirko Y, Blume Y BMC Genomics. 2024; 25(1):599.

PMID: 38877397 PMC: 11177405. DOI: 10.1186/s12864-024-10503-y.

Isolation and proteomic study of fish liver lipid droplets.

Sun Y, Heng J, Liu F, Zhang S, Liu P Biophys Rep. 2023; 9(3):120-133.

PMID: 38028150 PMC: 10648235. DOI: 10.52601/bpr.2023.230004.

Intrabacterial lipid inclusion-associated proteins: a core machinery conserved from saprophyte Actinobacteria to the human pathogen Mycobacterium tuberculosis.

Dargham T, Mallick I, Kremer L, Santucci P, Canaan S FEBS Open Bio. 2023; 13(12):2306-2323.

PMID: 37872001 PMC: 10699116. DOI: 10.1002/2211-5463.13721.

References

Cornejo E, Abreu N, Komeili A . Compartmentalization and organelle formation in bacteria. Curr Opin Cell Biol. 2014; 26:132-8. PMC: 4318566. DOI: 10.1016/j.ceb.2013.12.007. View

Wang Y, Zhou X, Ma X, Du Y, Zheng L, Liu P . Construction of Nanodroplet/Adiposome and Artificial Lipid Droplets. ACS Nano. 2016; 10(3):3312-22. DOI: 10.1021/acsnano.5b06852. View

Zhang P, Na H, Liu Z, Zhang S, Xue P, Chen Y . Proteomic study and marker protein identification of Caenorhabditis elegans lipid droplets. Mol Cell Proteomics. 2012; 11(8):317-28. PMC: 3412964. DOI: 10.1074/mcp.M111.016345. View

Rowe E, Mimmack M, Barbosa A, Haider A, Isaac I, Ouberai M . Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3. J Biol Chem. 2016; 291(13):6664-78. PMC: 4807253. DOI: 10.1074/jbc.M115.691048. View

Bartz R, Zehmer J, Zhu M, Chen Y, Serrero G, Zhao Y . Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J Proteome Res. 2007; 6(8):3256-65. DOI: 10.1021/pr070158j. View

OMahony F, Wroblewski K, OByrne S, Jiang H, Clerkin K, Benhammou J . Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein. Hepatology. 2014; 62(2):615-26. PMC: 4458237. DOI: 10.1002/hep.27645. View

Alvarez H, Steinbuchel A . Triacylglycerols in prokaryotic microorganisms. Appl Microbiol Biotechnol. 2002; 60(4):367-76. DOI: 10.1007/s00253-002-1135-0. View

Wan H, Melo R, Jin Z, Dvorak A, Weller P . Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies. FASEB J. 2006; 21(1):167-78. PMC: 2715426. DOI: 10.1096/fj.06-6711com. View

Ohsaki Y, Kawai T, Yoshikawa Y, Cheng J, Jokitalo E, Fujimoto T . PML isoform II plays a critical role in nuclear lipid droplet formation. J Cell Biol. 2016; 212(1):29-38. PMC: 4700481. DOI: 10.1083/jcb.201507122. View

10.

Ueno M, Shen W, Patel S, Greenberg A, Azhar S, Kraemer F . Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress. J Lipid Res. 2012; 54(3):734-743. PMC: 3617947. DOI: 10.1194/jlr.M033365. View

11.

Dvorak A, Morgan E, Weller P . RNA is closely associated with human mast cell lipid bodies. Histol Histopathol. 2003; 18(3):943-68. DOI: 10.14670/HH-18.943. View

12.

Li Z, Johnson M, Ke Z, Chen L, Welte M . Drosophila lipid droplets buffer the H2Av supply to protect early embryonic development. Curr Biol. 2014; 24(13):1485-91. PMC: 4122669. DOI: 10.1016/j.cub.2014.05.022. View

13.

Peramuna A, Summers M . Composition and occurrence of lipid droplets in the cyanobacterium Nostoc punctiforme. Arch Microbiol. 2014; 196(12):881-90. PMC: 4233187. DOI: 10.1007/s00203-014-1027-6. View

14.

Ploegh H . A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum. Nature. 2007; 448(7152):435-8. DOI: 10.1038/nature06004. View

15.

Farese Jr R, Walther T . Lipid droplets finally get a little R-E-S-P-E-C-T. Cell. 2009; 139(5):855-60. PMC: 3097139. DOI: 10.1016/j.cell.2009.11.005. View

16.

Edwards M, Berns D, Ghiorse W, Holt S . ULTRASTRUCTURE OF THE THERMOPHILIC BLUE-GREEN ALGA, SYNECHOCOCCUS LIVIDUS COPELAND(1). J Phycol. 2016; 4(4):283-98. DOI: 10.1111/j.1529-8817.1968.tb04697.x. View

17.

Liu Z, Li X, Ge Q, Ding M, Huang X . A lipid droplet-associated GFP reporter-based screen identifies new fat storage regulators in C. elegans. J Genet Genomics. 2014; 41(5):305-13. DOI: 10.1016/j.jgg.2014.03.002. View

18.

Li L, Walsh R, Wagh V, James M, Beauchamp R, Chang Y . Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency. PLoS One. 2015; 10(10):e0140192. PMC: 4596692. DOI: 10.1371/journal.pone.0140192. View

19.

Chen Y, Ding Y, Yang L, Yu J, Liu G, Wang X . Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630. Nucleic Acids Res. 2013; 42(2):1052-64. PMC: 3902926. DOI: 10.1093/nar/gkt932. View

20.

Cermelli S, Guo Y, Gross S, Welte M . The lipid-droplet proteome reveals that droplets are a protein-storage depot. Curr Biol. 2006; 16(18):1783-95. DOI: 10.1016/j.cub.2006.07.062. View