Neurological and Motor Disorders: Neuronal Store-Operated Ca Signaling: An Overview and Its Function

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2017 Sep 14

PMID 28900932

Citations 17

Authors

Sunitha Bollimuntha

Biswaranjan Pani

Brij B Singh

Affiliations

Soon will be listed here.

Abstract

Calcium (Ca) is a ubiquitous second messenger that performs significant physiological task such as neurosecretion, exocytosis, neuronal growth/differentiation, and the development and/or maintenance of neural circuits. An important regulatory aspect of neuronal Ca homeostasis is store-operated Ca entry (SOCE) which, in recent years, has gained much attention for influencing a variety of nerve cell responses. Essentially, activation of SOCE ensues following the activation of the plasma membrane (PM) store-operated Ca channels (SOCC) triggered by the depletion of endoplasmic reticulum (ER) Ca stores. In addition to the TRPC (transient receptor potential canonical) and the Orai family of ion channels, STIM (stromal interacting molecule) proteins have been baptized as key molecular regulators of SOCE. Functional significance of the TRPC channels in neurons has been elaborately studied; however, information on Orai and STIM components of SOCE, although seems imminent, is currently limited. Importantly, perturbations in SOCE have been implicated in a spectrum of neuropathological conditions. Hence, understanding the precise involvement of SOCC in neurodegeneration would presumably unveil avenues for plausible therapeutic interventions. We thus review the role of SOCE-regulated neuronal Ca signaling in selecting neurodegenerative conditions.

Citing Articles

Combined treatment targeting Ca2+ store mediated Ca2+ release and store-operated calcium entry reduces secondary axonal degeneration and improves functional outcome after SCI.

Jones E, Ames S, Brooks J, Morehouse J, Hill N, Mikoshiba K Exp Neurol. 2025; 386:115178.

PMID: 39909217 PMC: 11875899. DOI: 10.1016/j.expneurol.2025.115178.

Calcium Ions in the Physiology and Pathology of the Central Nervous System.

Pikor D, Hurla M, Slowikowski B, Szymanowicz O, Poszwa J, Banaszek N Int J Mol Sci. 2024; 25(23).

PMID: 39684844 PMC: 11642227. DOI: 10.3390/ijms252313133.

A bright cyan fluorescence calcium indicator for mitochondrial calcium with minimal interference from physiological pH fluctuations.

Gu W, Yang Y, Wang Y, Li J, Li W, Zhang X Biophys Rep. 2024; 10(5):315-327.

PMID: 39539283 PMC: 11554577. DOI: 10.52601/bpr.2024.240001.

Highly efficient Ca chelation activated by visible light.

Egodawaththa N, Rajhel O, Ma J, Guruge C, Pabarue A, Harris E Org Biomol Chem. 2024; 22(35):7194-7202.

PMID: 39161284 PMC: 11717440. DOI: 10.1039/d4ob00951g.

A Review of the Gene Family: Its Role in Neurological Disorders.

Szymanowicz O, Druzdz A, Slowikowski B, Pawlak S, Potocka E, Goutor U Diseases. 2024; 12(5).

PMID: 38785745 PMC: 11119137. DOI: 10.3390/diseases12050090.

References

Dulneva A, Lee S, Oliver P, Di Gleria K, Kessler B, Davies K . The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum. Hum Mol Genet. 2015; 24(14):4114-25. PMC: 4476454. DOI: 10.1093/hmg/ddv150. View

Balzer M, Lintschinger B, Groschner K . Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells. Cardiovasc Res. 1999; 42(2):543-9. DOI: 10.1016/s0008-6363(99)00025-5. View

Sattler R, Tymianski M . Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med (Berl). 2000; 78(1):3-13. DOI: 10.1007/s001090000077. View

Bojarski L, Pomorski P, Szybinska A, Drab M, Skibinska-Kijek A, Gruszczynska-Biegala J . Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease. Biochim Biophys Acta. 2008; 1793(6):1050-7. DOI: 10.1016/j.bbamcr.2008.11.008. View

Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J . The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress. Cell Death Dis. 2013; 4:e470. PMC: 3564003. DOI: 10.1038/cddis.2012.216. View

Selvaraj S, Sun Y, Watt J, Wang S, Lei S, Birnbaumer L . Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. J Clin Invest. 2012; 122(4):1354-67. PMC: 3314472. DOI: 10.1172/JCI61332. View

Miller B . The role of TRP channels in oxidative stress-induced cell death. J Membr Biol. 2006; 209(1):31-41. DOI: 10.1007/s00232-005-0839-3. View

Putney J . Alternative forms of the store-operated calcium entry mediators, STIM1 and Orai1. Curr Top Membr. 2013; 71:109-23. DOI: 10.1016/B978-0-12-407870-3.00005-6. View

Kirichok Y, Krapivinsky G, Clapham D . The mitochondrial calcium uniporter is a highly selective ion channel. Nature. 2004; 427(6972):360-4. DOI: 10.1038/nature02246. View

10.

Philipp S, Hambrecht J, Braslavski L, Schroth G, Freichel M, Murakami M . A novel capacitative calcium entry channel expressed in excitable cells. EMBO J. 1998; 17(15):4274-82. PMC: 1170761. DOI: 10.1093/emboj/17.15.4274. View

11.

van de Leemput J, Chandran J, Knight M, Holtzclaw L, Scholz S, Cookson M . Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genet. 2007; 3(6):e108. PMC: 1892049. DOI: 10.1371/journal.pgen.0030108. View

12.

Norman J, Perry S, Reynolds H, Kiebala M, Bentley K, Trejo M . HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. PLoS One. 2008; 3(11):e3731. PMC: 2579580. DOI: 10.1371/journal.pone.0003731. View

13.

Albers D, Beal M . Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J Neural Transm Suppl. 2000; 59:133-54. DOI: 10.1007/978-3-7091-6781-6_16. View

14.

Montell C . TRP channels in Drosophila photoreceptor cells. J Physiol. 2005; 567(Pt 1):45-51. PMC: 1474165. DOI: 10.1113/jphysiol.2005.092551. View

15.

Sun Y, Sukumaran P, Bandyopadhyay B, Singh B . Physiological Function and Characterization of TRPCs in Neurons. Cells. 2014; 3(2):455-75. PMC: 4092863. DOI: 10.3390/cells3020455. View

16.

Goonasekera S, Davis J, Kwong J, Accornero F, Wei-LaPierre L, Sargent M . Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Hum Mol Genet. 2014; 23(14):3706-15. PMC: 4065147. DOI: 10.1093/hmg/ddu079. View

17.

Brini M, Carafoli E . Calcium pumps in health and disease. Physiol Rev. 2009; 89(4):1341-78. DOI: 10.1152/physrev.00032.2008. View

18.

Berridge M . Capacitative calcium entry. Biochem J. 1995; 312 ( Pt 1):1-11. PMC: 1136219. DOI: 10.1042/bj3120001. View

19.

Ermak G, Davies K . Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol. 2002; 38(10):713-21. DOI: 10.1016/s0161-5890(01)00108-0. View

20.

Masliah E, Ge N, Mucke L . Pathogenesis of HIV-1 associated neurodegeneration. Crit Rev Neurobiol. 1996; 10(1):57-67. DOI: 10.1615/critrevneurobiol.v10.i1.30. View