Determination of Risk Factors Affecting the In-hospital Prognosis of Patients with Acute ST Segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention

Overview

Journal BMC Cardiovasc Disord

Publisher Biomed Central

Specialty Cardiology & Vascular Diseases

Date 2017 Sep 14

PMID 28899364

Citations 9

Authors

Rui Wang

Biqi Mei

Xinlong Liao

Xia Lu

Lulu Yan

Man Lin

Yao Zhong

Yili Chen

Tianhui You

Affiliations

Soon will be listed here.

Abstract

Background: To determine the factors affecting the in-hospital prognosis of patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI), and to establish its prognostic discriminant model.

Methods: A total of 701 consecutive STEMI patients undergoing PCI were enrolled in this study. The patients were divided into two groups, good prognosis and poor prognosis, based on whether the patient had adverse outcomes (death or heart function ≥ grade III) at discharge. Demographic and basic clinical characteristics, diagnosis at admission (e.g., ventricular function, complications, or hyperlipidemia), and biomedical indicators (e.g., blood count, basal metabolism and biochemical composition, blood lipid and glucose levels, myocardial biomarkers, and coagulation) were collected and analyzed.

Results: We determined 22 factors as risk factors for the in-hospital prognosis of STEMI patients after PCI: age, cardiac function during hospitalization, complications, history of diabetes mellitus, et al., among which the history of diabetes, uric acid, urea nitrogen, and activated partial thromboplastin time (APTT) were independent risk factors.

Conclusion: We identified four independent risk factors for the in-hospital prognosis of STEMI patients after PCI and generated a prognostic model to predict the adverse outcomes of these patients.

Citing Articles

Application of Machine Learning Algorithms in Predicting Major Adverse Cardiovascular Events after Percutaneous Coronary Intervention in Patients with New-Onset ST-Segment Elevation Myocardial Infarction.

Chen M, Sun C, Yang L, Zhang T, Zhang J, Chen C Rev Cardiovasc Med. 2025; 26(2):25758.

PMID: 40026513 PMC: 11868916. DOI: 10.31083/RCM25758.

HDL Subclasses and the Distribution of Paraoxonase-1 Activity in Patients with ST-Segment Elevation Acute Myocardial Infarction.

Djekic S, Vekic J, Zeljkovic A, Kotur-Stevuljevic J, Kafedzic S, Zdravkovic M Int J Mol Sci. 2023; 24(11).

PMID: 37298334 PMC: 10253951. DOI: 10.3390/ijms24119384.

The baseline and repeated measurements of DBP to assess in-hospital mortality risk among critically ill patients with acute myocardial infarction: A retrospective cohort study.

Huang S, Luo Y, Liang L, Guo N, Duan X, Zhou Q Medicine (Baltimore). 2022; 101(40):e30980.

PMID: 36221379 PMC: 9543008. DOI: 10.1097/MD.0000000000030980.

Cholesterol affects the relationship between albumin and major adverse cardiac events in patients with coronary artery disease: a secondary analysis.

Yao Y, Chen Z, Luo T, Dou X, Chen H Sci Rep. 2022; 12(1):12634.

PMID: 35879423 PMC: 9314340. DOI: 10.1038/s41598-022-16963-0.

Sarcopenia predicts adverse outcomes in an elderly population with coronary artery disease: a systematic review and meta-analysis.

Xue Q, Wu J, Ren Y, Hu J, Yang K, Cao J BMC Geriatr. 2021; 21(1):493.

PMID: 34521369 PMC: 8439080. DOI: 10.1186/s12877-021-02438-w.

References

McManus D, Gore J, Yarzebski J, Spencer F, Lessard D, Goldberg R . Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI. Am J Med. 2010; 124(1):40-7. PMC: 3011975. DOI: 10.1016/j.amjmed.2010.07.023. View

Kenchaiah S, Pfeffer M, St John Sutton M, Plappert T, Rouleau J, Lamas G . Effect of antecedent systemic hypertension on subsequent left ventricular dilation after acute myocardial infarction (from the Survival and Ventricular Enlargement trial). Am J Cardiol. 2004; 94(1):1-8. DOI: 10.1016/j.amjcard.2004.03.020. View

Feig D, Kang D, Johnson R . Uric acid and cardiovascular risk. N Engl J Med. 2008; 359(17):1811-21. PMC: 2684330. DOI: 10.1056/NEJMra0800885. View

Pedersen F, Butrymovich V, Kelbaek H, Wachtell K, Helqvist S, Kastrup J . Short- and long-term cause of death in patients treated with primary PCI for STEMI. J Am Coll Cardiol. 2014; 64(20):2101-8. DOI: 10.1016/j.jacc.2014.08.037. View

Honda T, Kanazawa H, Koga H, Miyao Y, Fujimoto K . Heart rate on admission is an independent risk factor for poor cardiac function and in-hospital death after acute myocardial infarction. J Cardiol. 2010; 56(2):197-203. DOI: 10.1016/j.jjcc.2010.05.006. View

Thygesen K, Alpert J, Jaffe A, Simoons M, Chaitman B, White H . Third universal definition of myocardial infarction. Glob Heart. 2015; 7(4):275-95. DOI: 10.1016/j.gheart.2012.08.001. View

Vrints C . Pathophysiology of the no-reflow phenomenon. Acute Card Care. 2009; 11(2):69-76. DOI: 10.1080/17482940902978061. View

Salwa P, Gorczyca-Michta I, Wozakowska-Kaplon B . The relationship between admission heart rate and early prognosis in patients with ST-elevation myocardial infarction. Kardiol Pol. 2014; 73(3):177-82. DOI: 10.5603/KP.a2014.0171. View

Sala J, Masia R, Fernandez-Real J, Gil M, Bosch D, Ricart W . Short-term mortality of myocardial infarction patients with diabetes or hyperglycaemia during admission. J Epidemiol Community Health. 2002; 56(9):707-12. PMC: 1732251. DOI: 10.1136/jech.56.9.707. View

10.

Chen L, Li X, Qiao W, Ying Z, Qin Y, Wang Y . Serum uric acid in patients with acute ST-elevation myocardial infarction. World J Emerg Med. 2014; 3(1):35-9. PMC: 4129817. DOI: 10.5847/wjem.j.issn.1920-8642.2012.01.006. View

11.

Kovar D, Cannon C, Bentley J, Charlesworth A, Rogers W . Does initial and delayed heart rate predict mortality in patients with acute coronary syndromes?. Clin Cardiol. 2004; 27(2):80-6. PMC: 6653939. DOI: 10.1002/clc.4960270207. View

12.

Kojima S, Sakamoto T, Ishihara M, Kimura K, Miyazaki S, Yamagishi M . Prognostic usefulness of serum uric acid after acute myocardial infarction (the Japanese Acute Coronary Syndrome Study). Am J Cardiol. 2005; 96(4):489-95. DOI: 10.1016/j.amjcard.2005.04.007. View

13.

Hiew C, Williams T, Hatton R, Narasimhan S, OConnor S, Baker F . Influence of age on long-term outcome after emergent percutaneous coronary intervention for ST-elevation myocardial infarction. J Invasive Cardiol. 2010; 22(6):273-7. View

14.

Metivier F, Marchais S, Guerin A, Pannier B, London G . Pathophysiology of anaemia: focus on the heart and blood vessels. Nephrol Dial Transplant. 2000; 15 Suppl 3:14-8. DOI: 10.1093/oxfordjournals.ndt.a027970. View

15.

Shpektor A . Cardiogenic shock: the role of inflammation. Acute Card Care. 2010; 12(4):115-8. DOI: 10.3109/17482941.2010.523705. View

16.

Newell M, Henry J, Henry T, Duval S, Browning J, Christiansen E . Impact of age on treatment and outcomes in ST-elevation myocardial infarction. Am Heart J. 2011; 161(4):664-72. DOI: 10.1016/j.ahj.2010.12.018. View

17.

Gawaz M, Neumann F, Ott I, Schiessler A, Schomig A . Platelet function in acute myocardial infarction treated with direct angioplasty. Circulation. 1996; 93(2):229-37. DOI: 10.1161/01.cir.93.2.229. View

18.

Wasserman A, Shnell M, Boursi B, Guzner-Gur H . Prognostic significance of serum uric acid in patients admitted to the Department of Medicine. Am J Med Sci. 2009; 339(1):15-21. DOI: 10.1097/MAJ.0b013e3181bbb647. View

19.

OGara P, Kushner F, Ascheim D, Casey Jr D, Chung M, de Lemos J . 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2012; 61(4):485-510. DOI: 10.1016/j.jacc.2012.11.018. View

20.

Parodi G, Bellandi B, Valenti R, Memisha G, Giuliani G, Velluzzi S . Heart rate as an independent prognostic risk factor in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Atherosclerosis. 2010; 211(1):255-9. DOI: 10.1016/j.atherosclerosis.2010.02.017. View