Bordetella Adenylate Cyclase-Hemolysin Toxins

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2017 Sep 12

PMID 28892012

Citations 20

Authors

Nicole Guiso

Affiliations

Soon will be listed here.

Abstract

Adenylate cyclase-hemolysin toxin is secreted and produced by three classical species of the genus : , and . This toxin has several properties such as: (i) adenylate cyclase activity, enhanced after interaction with the eukaryotic protein, calmodulin; (ii) a pore-forming activity; (iii) an invasive activity. It plays an important role in the pathogenesis of these species responsible for whooping cough in humans or persistent respiratory infections in mammals, by modulating host immune responses. In contrast with other toxins or adhesins, lack of (or very low polymorphism) is observed in the structural gene encoding this toxin, supporting its importance as well as a potential role as a vaccine antigen against whooping cough. In this article, an overview of the investigations undertaken on this toxin is presented.

Citing Articles

CyaA translocation across eukaryotic cell membranes.

Abettan A, Nguyen M, Ladant D, Monticelli L, Chenal A Front Mol Biosci. 2024; 11:1359408.

PMID: 38584704 PMC: 10995232. DOI: 10.3389/fmolb.2024.1359408.

Miguelena Chamorro B, De Luca K, Swaminathan G, Longet S, Mundt E, Paul S Clin Microbiol Rev. 2023; 36(3):e0016422.

PMID: 37306571 PMC: 10512794. DOI: 10.1128/cmr.00164-22.

A Robust and Sensitive Spectrophotometric Assay for the Enzymatic Activity of Bacterial Adenylate Cyclase Toxins.

Davi M, Sadi M, Pitard I, Chenal A, Ladant D Toxins (Basel). 2022; 14(10).

PMID: 36287960 PMC: 9609896. DOI: 10.3390/toxins14100691.

Design of a Quantitative LC-MS Method for Residual Toxins Adenylate Cyclase Toxin (ACT), Dermonecrotic Toxin (DNT) and Tracheal Cytotoxin (TCT) in Vaccines.

Szymkowicz L, Gerard J, Messham B, Tam W, James D Toxins (Basel). 2021; 13(11).

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Pathogenicity and virulence of and its adaptation to its strictly human host.

Belcher T, Dubois V, Rivera-Millot A, Locht C, Jacob-Dubuisson F Virulence. 2021; 12(1):2608-2632.

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