Elements of the Niche for Adult Stem Cell Expansion

Overview

Journal J Tissue Eng

Date 2017 Sep 12

PMID 28890779

Citations 21

Authors

Patricia A Redondo

Marina Pavlou

Marilena Loizidou

Umber Cheema

Affiliations

Soon will be listed here.

Abstract

Adult stem cells are crucial for tissue homeostasis. These cells reside within exclusive locations in tissues, termed niches, which protect adult stem cell fidelity and regulate their many functions through biophysical-, biochemical- and cellular-mediated mechanisms. There is a growing understanding of how these mechanisms and their components contribute towards maintaining stem cell quiescence, self-renewal, expansion and differentiation patterns. In vitro expansion of adult stem cells is a powerful tool for understanding stem cell biology, and for tissue engineering and regenerative medicine applications. However, it is technically challenging, since adult stem cell removal from their native microenvironment has negative repercussions on their sustainability. In this review, we overview specific elements of the biomimetic niche and how recreating such elements can help in vitro propagation of adult stem cells.

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References

Balordi F, Fishell G . Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons. J Neurosci. 2007; 27(22):5936-47. PMC: 6672245. DOI: 10.1523/JNEUROSCI.1040-07.2007. View

Aberg M, Aberg N, Palmer T, Alborn A, Carlsson-Skwirut C, Bang P . IGF-I has a direct proliferative effect in adult hippocampal progenitor cells. Mol Cell Neurosci. 2003; 24(1):23-40. DOI: 10.1016/s1044-7431(03)00082-4. View

Powell D, Pinchuk I, Saada J, Chen X, Mifflin R . Mesenchymal cells of the intestinal lamina propria. Annu Rev Physiol. 2010; 73:213-37. PMC: 3754809. DOI: 10.1146/annurev.physiol.70.113006.100646. View

Sagar B, Rentala S, Gopal P, Sharma S, Mukhopadhyay A . Fibronectin and laminin enhance engraftibility of cultured hematopoietic stem cells. Biochem Biophys Res Commun. 2006; 350(4):1000-5. DOI: 10.1016/j.bbrc.2006.09.140. View

Gerber H, Malik A, Solar G, Sherman D, Liang X, Meng G . VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature. 2002; 417(6892):954-8. DOI: 10.1038/nature00821. View

Cosgrove B, Gilbert P, Porpiglia E, Mourkioti F, Lee S, Corbel S . Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nat Med. 2014; 20(3):255-64. PMC: 3949152. DOI: 10.1038/nm.3464. View

Halder G, Dupont S, Piccolo S . Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat Rev Mol Cell Biol. 2012; 13(9):591-600. DOI: 10.1038/nrm3416. View

Kurth I, Franke K, Pompe T, Bornhauser M, Werner C . Hematopoietic stem and progenitor cells in adhesive microcavities. Integr Biol (Camb). 2009; 1(5-6):427-34. DOI: 10.1039/b903711j. View

Chen Y, Lee S, Tsai Y, Tseng S . Ischemic preconditioning increased the intestinal stem cell activities in the intestinal crypts in mice. J Surg Res. 2013; 187(1):85-93. DOI: 10.1016/j.jss.2013.10.001. View

10.

Qu Q, Sun G, Li W, Yang S, Ye P, Zhao C . Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat Cell Biol. 2009; 12(1):31-40. PMC: 2880892. DOI: 10.1038/ncb2001. View

11.

Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T . Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood. 2012; 119(23):5429-37. PMC: 3418770. DOI: 10.1182/blood-2011-11-393645. View

12.

Regalado-Santiago C, Juarez-Aguilar E, Olivares-Hernandez J, Tamariz E . Mimicking Neural Stem Cell Niche by Biocompatible Substrates. Stem Cells Int. 2016; 2016:1513285. PMC: 4736764. DOI: 10.1155/2016/1513285. View

13.

Dupont S . Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction. Exp Cell Res. 2015; 343(1):42-53. DOI: 10.1016/j.yexcr.2015.10.034. View

14.

He N, Zhang L, Cui J, Li Z . Bone marrow vascular niche: home for hematopoietic stem cells. Bone Marrow Res. 2014; 2014:128436. PMC: 4009113. DOI: 10.1155/2014/128436. View

15.

Jansson L, Larsson J . Normal hematopoietic stem cell function in mice with enforced expression of the Hippo signaling effector YAP1. PLoS One. 2012; 7(2):e32013. PMC: 3283704. DOI: 10.1371/journal.pone.0032013. View

16.

Faissner A, Roll L, Theocharidis U . Tenascin-C in the matrisome of neural stem and progenitor cells. Mol Cell Neurosci. 2016; 81:22-31. DOI: 10.1016/j.mcn.2016.11.003. View

17.

Androutsellis-Theotokis A, Walbridge S, Park D, Lonser R, McKay R . Cholera toxin regulates a signaling pathway critical for the expansion of neural stem cell cultures from the fetal and adult rodent brains. PLoS One. 2010; 5(5):e10841. PMC: 2877108. DOI: 10.1371/journal.pone.0010841. View

18.

Csaszar E, Kirouac D, Yu M, Wang W, Qiao W, Cooke M . Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell. 2012; 10(2):218-29. DOI: 10.1016/j.stem.2012.01.003. View

19.

Hardwick J, van den Brink G, Bleuming S, Ballester I, van den Brande J, Keller J . Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon. Gastroenterology. 2003; 126(1):111-21. DOI: 10.1053/j.gastro.2003.10.067. View

20.

Cuchiara M, Coskun S, Banda O, Horter K, Hirschi K, West J . Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. Biotechnol Bioeng. 2015; 113(4):870-81. DOI: 10.1002/bit.25848. View