Positive Regulation of TAZ Expression by EBV-LMP1 Contributes to Cell Proliferation and Epithelial-mesenchymal Transition in Nasopharyngeal Carcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Sep 9

PMID 28881733

Citations 13

Authors

Jiang He

Feiyu Tang

Liyu Liu

Lin Chen

Jiang Li

Danming Ou

Lu Zhang

Zhi Li

Deyun Feng

Wenzheng Li

Lun-Quan Sun

Affiliations

Soon will be listed here.

Abstract

The Epstein-Barr virus latent membrane protein 1 (LMP1) is an integral membrane protein. LMP1 has been reported to activate the NF-κB and mitogen-activated protein kinase pathways. However, these effects alone are unable to account for the profound oncogenic properties of LMP1. TAZ is one of the nuclear effectors of Hippo-related pathways and highly expressed in many human tumors. Here, we reported that TAZ was frequently expressed in LMP1-positive nasopharyngeal carcinoma. In NPC cell lines, we showed that LMP1 promoted TAZ expression. Gelsolin is an important inhibitor of TAZ activity. Our studies showed that LMP1 interacted with gelsolin, resulting in inhibition of Lats1/2 phosphorylation and improvement of TAZ stability. Furthermore, we revealed that TAZ is important for LMP1-mediated cell proliferation, cancer stem cell-like properties and epithelial-mesenchymal transition. These findings provide new insights into the carcinogenic roles of LMP1 and contribute to further understanding of its oncogenic mechanism.

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