Effects of Dopamine Receptor Antagonists on Gastrin and Vomiting Responses to Apomorphine

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1987 Jul 1

PMID 2888024

Citations 3

Authors

M Goiny

K Uvnas-Moberg

Affiliations

Soon will be listed here.

Abstract

Apomorphine (0.05 mg/kg intravenously) was given to conscious dogs, and gastrin levels were measured in peripheral venous blood with a radioimmunoassay. Apomorphine induced an increase of gastrin levels which peaked at 5 min. The peripheral dopamine D-2/DA2 receptor antagonist domperidone (0.2 mg/kg), but not halopemide (0.1-1 mg/kg) nor the D-1/DA1 receptor antagonist SCH 23,390 (0.1 mg/kg), blocked the gastrin response to apomorphine. Both domperidone and halopemide, but not SCH 23,390, blocked the apomorphine-induced vomiting. These results suggest that apomorphine increases gastrin levels by an action at D-2/DA2 receptors, which are situated outside the blood brain barrier and differ from the receptor inducing the vomiting.

Citing Articles

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Auffret M, Drapier S, Verin M Drugs R D. 2018; 18(2):91-107.

PMID: 29546602 PMC: 5995787. DOI: 10.1007/s40268-018-0230-3.

A long lasting gastrin response to apomorphine revealed by inhibitors of gastric acid secretion.

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Dopamine in gastrointestinal disease.

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