Dopamine in Gastrointestinal Disease

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1990 Sep 1

PMID 2202571

Citations 28

Authors

G B Glavin

S Szabo

Affiliations

Soon will be listed here.

Abstract

Dopamine is an important enteric neuromodulator. Herein we review the data that support a role for dopaminergic involvement in experimental duodenal and gastric ulceration; gastric, pancreatic, and duodenal secretion; gastrointestinal motility; and gastric and intestinal submucosal blood flow regulation. There also is support for a role for dopamine and dopamimetic agents in the treatment of certain experimental gastrointestinal diseases because some highly selective dopamine agonists are gastroprotective when given either parenterally or centrally. Based upon these observations, we suggest that dopamine is a key element of the "brain-gut axis" and represents a potentially important target for pharmacotherapeutic exploitation.

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