Perfluorocarbon Emulsions Radiosensitise Brain Tumors in Carbogen Breathing Mice with Orthotopic GL261 Gliomas

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Sep 6

PMID 28873460

Citations 8

Authors

Lisa A Feldman

Marie-Sophie Fabre

Carole Grasso

Dana Reid

William C Broaddus

Gregory M Lanza

Bruce D Spiess

Joel R Garbow

Melanie J McConnell

Patries M Herst

Affiliations

Soon will be listed here.

Abstract

Background: Tumour hypoxia limits the effectiveness of radiation therapy. Delivering normobaric or hyperbaric oxygen therapy elevates pO2 in both tumour and normal brain tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy.

Aim: To investigate the effect of perfluorocarbon (PFC) emulsions on hypoxia in subcutaneous and intracranial mouse gliomas and their radiosensitising effect in orthotopic gliomas in mice breathing carbogen (95%O2 and 5%CO2).

Results: PFC emulsions completely abrogated hypoxia in both subcutaneous and intracranial GL261 models and conferred a significant survival advantage orthotopically (Mantel Cox: p = 0.048) in carbogen breathing mice injected intravenously (IV) with PFC emulsions before radiation versus mice receiving radiation alone. Carbogen alone decreased hypoxia levels substantially and conferred a smaller but not statistically significant survival advantage over and above radiation alone.

Conclusion: IV injections of PFC emulsions followed by 1h carbogen breathing, radiosensitises GL261 intracranial tumors.

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