Taurine Attenuates AsO-Induced Autophagy in Cerebrum of Mouse Through Nrf2 Pathway

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2017 Aug 30

PMID 28849506

Citations 3

Authors

Fengyuan Piao

Yan Zhang

Lijun Yang

Cong Zhang

Jing Shao

Xiaohui Liu

Yachen Li

Shuangyue Li

Affiliations

Soon will be listed here.

Abstract

We previously reported that the impairment of cerebrum may relate with neurotoxicity induced by arsenic (As) exposure. In the present study, we investigated whether autophagy of the cerebrum neurons were responsible for As-induced neurotoxicity and the protective role of taurine (Tau). Forty mice were randomly divided into control group, Tau control group, As exposure group and Tau protection group. The results showed that LC3 II expression was elevated and P62 expression was lower after As exposure, whereas the effects were obviously attenuated by Tau treatment. More important, As induced increase of MDA level and decrease of Nrf2 expression were significantly inversed in protective group. In sum, autophagy inhibition might play a strong role in the neuroprotection of Tau in As-induced toxicity via Nrf2 pathway.

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