Overexpression of Long Non-coding RNA Cancer Susceptibility 2 Inhibits Cell Invasion and Angiogenesis in Gastric Cancer

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2017 Aug 30

PMID 28849111

Citations 25

Authors

Jianfeng Zhou

Haiyan Huang

Shijie Tong

Rong Huo

Affiliations

Soon will be listed here.

Abstract

Increasing evidence has indicated that long non‑coding RNAs (lncRNAs) were aberrantly expressed and acted as key regulators in various types of disease, including cancer. lncRNA cancer susceptibility 2 (CASC2) has been found to be downregulated and acts as a tumor suppressor in various type of cancer, including gastric cancer (GC). However, the precise function of lncRNA CASC2 in GC remains unclear. In the present study, the expression level of lncRNA CASC2 in GC was investigated and the molecular mechanisms by which CASC2 acted as a tumor suppressor in this disease were elucidated. It was found that the expression level of lncRNA CASC2 was decreased, which correlated with TNM stages, vessel invasion, metastasis, and overall survival of patients with GC. Furthermore, overexpression of CASC2 inhibited the invasion and angiogenesis of GC cells. Thus, the present study indicated the important roles and underlying molecular mechanisms of lncRNA CASC2 on GC, and indicated that lncRNA CASC2 may present as a potential therapeutic target for the treatment of GC.

Citing Articles

The LINC01094/miR-545-3p/SLC7A11 Signaling Axis Promotes the Development of Gastric Cancer by Regulating Cell Growth and Ferroptosis.

Wang H, Li C, Meng S, Kuang Y Biochem Genet. 2024; .

PMID: 39540959 DOI: 10.1007/s10528-024-10959-3.

LINC01503 promotes the cell proliferation, migration and invasion of triple-negative breast cancer as a ceRNA to elevate SPNS2 expression by sponging miR-335-5p.

Weng W, Huang H Heliyon. 2024; 10(17):e36531.

PMID: 39296205 PMC: 11409029. DOI: 10.1016/j.heliyon.2024.e36531.

POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer.

Wang J, Jia Q, Jiang S, Lu W, Ning H Cell Biol Toxicol. 2024; 40(1):3.

PMID: 38267746 PMC: 10808632. DOI: 10.1007/s10565-024-09843-y.

LncRNA CASC2 Regulate Cell Proliferation and Invasion by Targeting miR-155/SOCS1 Axis in Hepatocellular Carcinoma.

Yuan Y, Ye J, Zhang X, Liu Z J Oncol. 2023; 2023:8457112.

PMID: 36816357 PMC: 9937765. DOI: 10.1155/2023/8457112.

The lncRNA ZNF667-AS1 Inhibits Propagation, Invasion, and Angiogenesis of Gastric Cancer by Silencing the Expression of N-Cadherin and VEGFA.

Yu C, Chen W, Cai Y, Du M, Zong D, Qian L J Oncol. 2022; 2022:3579547.

PMID: 35813862 PMC: 9270142. DOI: 10.1155/2022/3579547.

References

Chan T, Qamra A, Tan K, Guo J, Yang H, Qi L . ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer. Gastroenterology. 2016; 151(4):637-650.e10. PMC: 8286172. DOI: 10.1053/j.gastro.2016.06.043. View

Li P, Xue W, Feng Y, Mao Q . Long non-coding RNA CASC2 suppresses the proliferation of gastric cancer cells by regulating the MAPK signaling pathway. Am J Transl Res. 2016; 8(8):3522-9. PMC: 5009404. View

Batista P, Chang H . Long noncoding RNAs: cellular address codes in development and disease. Cell. 2013; 152(6):1298-307. PMC: 3651923. DOI: 10.1016/j.cell.2013.02.012. View

Livak K, Schmittgen T . Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2002; 25(4):402-8. DOI: 10.1006/meth.2001.1262. View

Yan Y, Han J, Li Z, Yang H, Sui Y, Wang M . Elevated RNA expression of long non‑coding HOTAIR promotes cell proliferation and predicts a poor prognosis in patients with diffuse large B cell lymphoma. Mol Med Rep. 2016; 13(6):5125-31. PMC: 4878541. DOI: 10.3892/mmr.2016.5190. View

Gutschner T, Diederichs S . The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 2012; 9(6):703-19. PMC: 3495743. DOI: 10.4161/rna.20481. View

Esteller M . Non-coding RNAs in human disease. Nat Rev Genet. 2011; 12(12):861-74. DOI: 10.1038/nrg3074. View

Wang P, Liu Y, Yao Y, Li Z, Li Z, Ma J . Long non-coding RNA CASC2 suppresses malignancy in human gliomas by miR-21. Cell Signal. 2014; 27(2):275-82. DOI: 10.1016/j.cellsig.2014.11.011. View

Huang G, Wu X, Li S, Xu X, Zhu H, Chen X . The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer. Sci Rep. 2016; 6:26524. PMC: 4873821. DOI: 10.1038/srep26524. View

10.

Torre L, Bray F, Siegel R, Ferlay J, Lortet-Tieulent J, Jemal A . Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65(2):87-108. DOI: 10.3322/caac.21262. View

11.

Hermanek P, HUTTER R, Sobin L, Wittekind C . International Union Against Cancer. Classification of isolated tumor cells and micrometastasis. Cancer. 1999; 86(12):2668-73. View

12.

Huang B, Song J, Cheng Y, Abraham J, Ibrahim S, Sun Z . Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression. Oncogene. 2016; 35(37):4927-36. PMC: 4985510. DOI: 10.1038/onc.2016.25. View

13.

Li H, Yu B, Li J, Su L, Yan M, Zhu Z . Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. Oncotarget. 2014; 5(8):2318-29. PMC: 4039165. DOI: 10.18632/oncotarget.1913. View

14.

Baldinu P, Cossu A, Manca A, Satta M, Sini M, Palomba G . CASC2a gene is down-regulated in endometrial cancer. Anticancer Res. 2007; 27(1A):235-43. View

15.

Lee J, Song J, Kwon E, Jo S, Kyung Kang M, Kim Y . CTHRC1 promotes angiogenesis by recruiting Tie2-expressing monocytes to pancreatic tumors. Exp Mol Med. 2016; 48(9):e261. PMC: 5050301. DOI: 10.1038/emm.2016.87. View

16.

Xie M, Nie F, Sun M, Xia R, Liu Y, Zhou P . Decreased long noncoding RNA SPRY4-IT1 contributing to gastric cancer cell metastasis partly via affecting epithelial-mesenchymal transition. J Transl Med. 2015; 13:250. PMC: 4522960. DOI: 10.1186/s12967-015-0595-9. View

17.

Lee J . Epigenetic regulation by long noncoding RNAs. Science. 2012; 338(6113):1435-9. DOI: 10.1126/science.1231776. View

18.

Herszenyi L, Tulassay Z . Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci. 2010; 14(4):249-58. View

19.

Zhu X, Tian X, Yu C, Shen C, Yan T, Hong J . A long non-coding RNA signature to improve prognosis prediction of gastric cancer. Mol Cancer. 2016; 15(1):60. PMC: 5029104. DOI: 10.1186/s12943-016-0544-0. View

20.

Hironaka S, Sugimoto N, Yamaguchi K, Moriwaki T, Komatsu Y, Nishina T . S-1 plus leucovorin versus S-1 plus leucovorin and oxaliplatin versus S-1 plus cisplatin in patients with advanced gastric cancer: a randomised, multicentre, open-label, phase 2 trial. Lancet Oncol. 2015; 17(1):99-108. DOI: 10.1016/S1470-2045(15)00410-6. View