Dynamic Reconfiguration of Cortical Functional Connectivity Across Brain States

Overview

Journal Sci Rep

Specialty Science

Date 2017 Aug 20

PMID 28821753

Citations 15

Authors

Iain Stitt

Karl J Hollensteiner

Edgar Galindo-Leon

Florian Pieper

Eva Fiedler

Thomas Stieglitz

Gerhard Engler

Guido Nolte

Andreas K Engel

Affiliations

Soon will be listed here.

Abstract

Throughout each day, the brain displays transient changes in state, as evidenced by shifts in behavior and vigilance. While the electrophysiological correlates of brain states have been studied for some time, it remains unclear how large-scale cortico-cortical functional connectivity systematically reconfigures across states. Here, we investigate state-dependent shifts in cortical functional connectivity by recording local field potentials (LFPs) during spontaneous behavioral transitions in the ferret using chronically implanted micro-electrocorticographic (µECoG) arrays positioned over occipital, parietal, and temporal cortical regions. To objectively classify brain state, we describe a data-driven approach that projects time-varying LFP spectral properties into brain state space. Distinct brain states displayed markedly different patterns of cross-frequency phase-amplitude coupling and inter-electrode phase synchronization across several LFP frequency bands. The largest across-state differences in functional connectivity were observed between periods of presumed slow-wave and rapid-eye-movement-sleep/active-state, which were characterized by the contrasting phenomena of cortical network fragmentation and global synchronization, respectively. Collectively, our data provide strong evidence that large-scale functional interactions in the brain dynamically reconfigure across behavioral states.

Citing Articles

Dynamic changes in large-scale functional connectivity prior to stimulation determine performance in a multisensory task.

Galindo-Leon E, Hollensteiner K, Pieper F, Engler G, Nolte G, Engel A Front Syst Neurosci. 2025; 19:1524547.

PMID: 40012905 PMC: 11860953. DOI: 10.3389/fnsys.2025.1524547.

Transient destabilization of interhemispheric functional connectivity induced by spreading depolarization.

Lachinova D, Smirnova M, Pavlova I, Sysoev I, Vinogradova L Netw Neurosci. 2024; 8(4):1383-1399.

PMID: 39735499 PMC: 11675007. DOI: 10.1162/netn_a_00405.

Functional hierarchies in brain dynamics characterized by signal reversibility in ferret cortex.

Idesis S, Geli S, Faskowitz J, Vohryzek J, Sanz Perl Y, Pieper F PLoS Comput Biol. 2024; 20(1):e1011818.

PMID: 38241383 PMC: 10836715. DOI: 10.1371/journal.pcbi.1011818.

Structural basis of envelope and phase intrinsic coupling modes in the cerebral cortex.

Messe A, Hollensteiner K, Delettre C, Dell-Brown L, Pieper F, Nentwig L Neuroimage. 2023; 276:120212.

PMID: 37269959 PMC: 10300241. DOI: 10.1016/j.neuroimage.2023.120212.

Coupled Dynamics of Stimulus-Evoked Gustatory Cortical and Basolateral Amygdalar Activity.

Mahmood A, Steindler J, Germaine H, Miller P, Katz D J Neurosci. 2022; 43(3):386-404.

PMID: 36443002 PMC: 9864615. DOI: 10.1523/JNEUROSCI.1412-22.2022.

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