Cost of Nosocomial Outbreak Caused by NDM-1-Containing Klebsiella Pneumoniae in the Netherlands, October 2015-January 2016

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2017 Aug 19

PMID 28820386

Citations 10

Authors

Madelief Mollers

Suzanne P Lutgens

Annelot F Schoffelen

Peter M Schneeberger

Anita W M Suijkerbuijk

Affiliations

Soon will be listed here.

Abstract

During October-December 2015, 29 patients in a hospital in the Netherlands acquired nosocomial infection with a multidrug-resistant, New Delhi-metallo-β-lactamase-positive Klebsiella pneumoniae strain. Extensive infection control measures were needed to stop this outbreak. The estimated economic impact of the outbreak was $804,263; highest costs were associated with hospital bed closures.

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References

Jiang Y, Resch S, Liu X, Rogers Jr S, Askari R, Klompas M . The Cost of Responding to an Acinetobacter Outbreak in Critically Ill Surgical Patients. Surg Infect (Larchmt). 2015; 17(1):58-64. DOI: 10.1089/sur.2015.036. View

Giske C, Monnet D, Cars O, Carmeli Y . Clinical and economic impact of common multidrug-resistant gram-negative bacilli. Antimicrob Agents Chemother. 2007; 52(3):813-21. PMC: 2258516. DOI: 10.1128/AAC.01169-07. View

Ayraud-Thevenot S, Huart C, Mimoz O, Taouqi M, Laland C, Bousseau A . Control of multi-drug-resistant Acinetobacter baumannii outbreaks in an intensive care unit: feasibility and economic impact of rapid unit closure. J Hosp Infect. 2012; 82(4):290-2. DOI: 10.1016/j.jhin.2012.08.016. View

Yong D, Toleman M, Giske C, Cho H, Sundman K, Lee K . Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 2009; 53(12):5046-54. PMC: 2786356. DOI: 10.1128/AAC.00774-09. View

Wassenberg M, Kluytmans J, Box A, Bosboom R, Buiting A, van Elzakker E . Rapid screening of methicillin-resistant Staphylococcus aureus using PCR and chromogenic agar: a prospective study to evaluate costs and effects. Clin Microbiol Infect. 2010; 16(12):1754-61. DOI: 10.1111/j.1469-0691.2010.03210.x. View