Association of Variably Expressed KIR3dl1 Alleles with Psoriatic Disease

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2017 Aug 13

PMID 28801811

Citations 10

Authors

Jeffrey Berinstein

Remy Pollock

Fawnda Pellett

Arane Thavaneswaran

Vinod Chandran

Dafna D Gladman

Affiliations

Soon will be listed here.

Abstract

The purpose of this study is to examine the genetic interaction of variably expressed killer cell immunoglobulin-like receptor (KIR) 3DL1 alleles with their cognate ligand, human leukocyte antigen (HLA)-Bw4, in susceptibility to psoriatic disease (PsD). A novel allelic typing system was developed to differentiate KIR3DL1 alleles (*High, *Low, *Null expression, and 3DS1), in PsD patients, including those with psoriatic arthritis (PsA) and cutaneous psoriasis without arthritis (PsC) and healthy controls. Frequencies of each KIR3DL1 allele, Bw4-80I and Bw4-80T, as well as the genetic interaction between the KIR3DL1 alleles and the Bw4 epitope were analyzed. KIR3DL1 alleles were successfully genotyped in 392 PsA, 260 PsC, and 371 control subjects. Only the KIR3DL1*Null allele was associated with PsD (OR = 0.69, p = 0.008), both in the PsA (OR = 0.69, p = 0.02) and PsC patients (OR = 0.70, p = 0.04) compared to control subjects. No difference in the frequency of KIR3DL1*Null was found between the PsA and PsC patients. The presence of the HLA-Bw4 epitope was significantly associated with PsD, particularly in the PsA patients compared to controls. Bw4-80I was increased in PsD and PsA subjects, but not in PsC patients compared to controls. Bw4-80T was increased in PsA compared to both PsC patients or to controls. No interaction was detected between any of the KIR3DL1 alleles and HLA-Bw4, Bw4-80I, or Bw4-80T. The novel qPCR technique successfully identified the four variably expressed KIR3DL1 alleles. The HLA-Bw4 epitope was associated with psoriatic disease, particularly with PsA, but no genetic interactions with KIR3DL1 alleles were detected.

Citing Articles

Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma.

Muriuki B, Forconi C, Kirwa E, Maina T, Ariera B, Bailey J PLoS One. 2023; 18(8):e0275046.

PMID: 37647275 PMC: 10468049. DOI: 10.1371/journal.pone.0275046.

Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1.

Harrison G, Leaton L, Harrison E, Kichula K, Viken M, Shortt J PLoS Comput Biol. 2022; 18(2):e1009059.

PMID: 35192601 PMC: 8896733. DOI: 10.1371/journal.pcbi.1009059.

ERAP1, ERAP2, and Two Copies of HLA-Aw19 Alleles Increase the Risk for Birdshot Chorioretinopathy in HLA-A29 Carriers.

Gelfman S, Monnet D, Ligocki A, Tabary T, Moscati A, Bai X Invest Ophthalmol Vis Sci. 2021; 62(14):3.

PMID: 34727153 PMC: 8572510. DOI: 10.1167/iovs.62.14.3.

Rheumatoid Arthritis Susceptibility Is Associated with the of Killer-Cell Immunoglobulin-Like Receptor Genes in the Lur Population of Iran.

Ansari-Moghaddam B, Kiani A, Sheikhian A, Birjandi M, Ahmadi S, Mousavi N Rep Biochem Mol Biol. 2021; 10(1):84-94.

PMID: 34277872 PMC: 8279711. DOI: 10.52547/rbmb.10.1.84.

Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis.

Ahn R, Vukcevic D, Motyer A, Nititham J, Squire D, Hollenbach J Front Immunol. 2021; 12:684326.

PMID: 34177931 PMC: 8231283. DOI: 10.3389/fimmu.2021.684326.

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