Diversity of KIR/HLA Genotypes and Their Association with Psoriasis Vulgaris in the Western Mexican Population

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2020 Apr 3

PMID 32235781

Citations 1

Authors

Omar Graciano-Machuca

Anabell Alvarado-Navarro

Maria Guadalupe Ramirez-Duenas

Delfina Guadalupe Villanueva-Quintero

Erandi Enif Velarde-de la Cruz

Andrea Carolina Machado-Sulbaran

Margarita Montoya-Buelna

Pedro Ernesto Sanchez-Hernandez

Affiliations

Soon will be listed here.

Abstract

NK and some T cell functions are regulated by the interaction between KIR and HLA molecules. Several studies have shown an association between activating genes and the development of autoimmune diseases, including psoriasis vulgaris (PsV). Our objective was to determine the association between genes and genotypes with PsV in the Western mestizo Mexican population. One hundred subjects diagnosed with PsV (SP) and 108 healthy subjects (HS) were genotyped for 14 genes, , , and by PCR-single specific primer (SSP). Positive associations of the gene (odds ratio (OR) 1.959, = 0.021), G11 genotype (OR 19.940, = 0.008), and (OR 2.265, = 0.009) were found with susceptibility to PsV. In contrast, the G1 genotype (OR 0.448, = 0.031) and (OR 0.522, = 0.022) were negatively associated with susceptibility to this disease. These results suggest an implication of the genotype in PsV pathology.

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Dubis J, Niepieklo-Miniewska W, Jedruchniewicz N, Sobczynski M, Witkiewicz W, Zapotoczny N Cells. 2021; 10(12).

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