HSC Niche Biology and HSC Expansion Ex Vivo

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2017 Aug 13

PMID 28801069

Citations 58

Authors

Sachin Kumar

Hartmut Geiger

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem cell (HSC) transplantation can restore a new functional hematopoietic system in recipients in cases where the system of the recipient is not functional or for example is leukemic. However, the number of available donor HSCs is often too low for successful transplantation. Expansion of HSCs and thus HSC self-renewal ex vivo would greatly improve transplantation therapy in the clinic. In vivo, HSCs expand significantly in the niche, but establishing protocols that result in HSC expansion ex vivo remains challenging. In this review we discuss current knowledge of niche biology, the intrinsic regulators of HSC self-renewal in vivo, and introduce novel niche-informed strategies of HSC expansion ex vivo.

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