Bioactive Calcium Phosphate-based Glasses and Ceramics and Their Biomedical Applications: A Review

Overview

Journal J Tissue Eng

Date 2017 Aug 11

PMID 28794848

Citations 44

Authors

Md Towhidul Islam

Reda M Felfel

Ensanya A Abou Neel

David M Grant

Ifty Ahmed

Kazi M Zakir Hossain

Affiliations

Soon will be listed here.

Abstract

An overview of the formation of calcium phosphate under in vitro environment on the surface of a range of bioactive materials (e.g. from silicate, borate, and phosphate glasses, glass-ceramics, bioceramics to metals) based on recent literature is presented in this review. The mechanism of bone-like calcium phosphate (i.e. hydroxyapatite) formation and the test protocols that are either already in use or currently being investigated for the evaluation of the bioactivity of biomaterials are discussed. This review also highlights the effect of chemical composition and surface charge of materials, types of medium (e.g. simulated body fluid, phosphate-buffered saline and cell culture medium) and test parameters on their bioactivity performance. Finally, a brief summary of the biomedical applications of these newly formed calcium phosphate (either in the form of amorphous or apatite) is presented.

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